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• W2004232279 abstract "The toxic unit concept is commonly applied for determining the effects of a mixture of toxicants. Use of this concept is, however, limited to compounds with similarly shaped dose-response relationships. In the present study, a method is proposed to gain insight regarding the influence of differences in the shapes of dose-response relationships on the applicability of the concentration-addition model by judging additivity at different effect levels. To this purpose, two model toxicants with different modes of action and dose-response relationships were selected: copper, and diazinon. Using mortality of the mayfly (Ephoron virgo) as the endpoint, it was demonstrated that the two compounds act in a less-than-concentration-additive manner. Application of the proposed calculation method revealed that the less-than-concentration-addition effect was independent of the effect level on which the mixture was judged." @default.
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• W2004232279 date "2000-01-01" @default.
• W2004232279 modified "2023-09-27" @default.
• W2004232279 title "MIXTURE TOXICITY OF COPPER AND DIAZINON TO LARVAE OF THE MAYFLY (EPHORON VIRGO) JUDGING ADDITIVITY AT DIFFERENT EFFECT LEVELS" @default.
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• W2004232279 doi "https://doi.org/10.1897/1551-5028(2000)019<2900:mtocad>2.0.co;2" @default.
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