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- W2004234041 abstract "Effect of moclobemide, a selective monoamine oxidase-type A enzyme inhibitor, was investigated on the body temperature of male mice. Moclobemide (15–30 mg kg−1, i.p.) produced significant reductions of body temperature in both normal and yeast-induced hyperthermic male mice. The hypothermic effect of moclobemide was moderate and short-lasting. Moclobemide-induced hypothermia was not antagonized by previous administration of prazosin (10 and 20 mg kg−1, s.c.), propranolol (5, 10, and 20 mg kg−1, s.c.), haloperidol (2 and 10 mg kg−1, s.c.), atropine (10 and 20 mg kg−1, s.c.), mepyramine (25 and 50 mg kg−1, s.c.), or methysergide (0.5, 1, and 2 mg kg−1, s.c.). Pretreatment with the opioid antagonist naloxone (10 mg kg−1, s.c.), however, was able to reverse the hypothermic effect of moclobemide (30 mg kg−1, i.p.) in both normal and yeast-induced hyperthermic mice. The present results indicate a possible role for central opioid receptors in the hypothermic effect of moclobemide. Also, a peripheral component for this effect of moclobemide at the mitochondria of peripheral tissues is suspected. The peripheral tissue mitochondria could be considered a common target for moclobemide and opioids actions on body temperature." @default.
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- W2004234041 date "2003-09-01" @default.
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- W2004234041 title "Possible involvement of opioid receptors in moclobemide-induced hypothermia in mice" @default.
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- W2004234041 doi "https://doi.org/10.1016/s1043-6618(03)00108-7" @default.
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