FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004236535> ?p ?o ?g. }

• W2004236535 endingPage "175" @default.
• W2004236535 startingPage "167" @default.
• W2004236535 abstract "Contractile dysfunction of the respiratory muscles plays an important role in the genesis of respiratory failure during sepsis. Nitric oxide (NO), a free radical that is cytotoxic and negatively inotropic in the heart and skeletal muscle, is produced in large amounts during sepsis by a NO synthase inducible (iNOS) by LPS and/or cytokines. The aim of this study was to investigate whether iNOS was induced in the diaphragm of Escherichia coli endotoxemic rats and whether inhibition of iNOS induction or of NOS synthesis attenuated diaphragmatic contractile dysfunction. Rats were inoculated intravenously (IV) with 10 mg/kg of E. coli endotoxin (LPS animals) or saline (C animals). Six hours after LPS inoculation animals showed a significant increase in diaphragmatic NOS activity (L-citrulline production, P < 0.005). Inducible NOS protein was detected by Western-Blot in the diaphragms of LPS animals, while it was absent in C animals. LPS animals had a significant decrease in diaphragmatic force (P < 0.0001) measured in vitro. In LPS animals, inhibition of iNOS induction with dexamethasone (4 mg/kg IV 45 min before LPS) or inhibition of NOS activity with N(G)-methyl-L-arginine (8 mg/kg IV 90 min after LPS) prevented LPS-induced diaphragmatic contractile dysfunction. We conclude that increased NOS activity due to iNOS was involved in the genesis of diaphragmatic dysfunction observed in E. coli endotoxemic rats." @default.
• W2004236535 created "2016-06-24" @default.
• W2004236535 creator A5007216227 @default.
• W2004236535 creator A5013821654 @default.
• W2004236535 creator A5023687827 @default.
• W2004236535 creator A5032875267 @default.
• W2004236535 creator A5051055282 @default.
• W2004236535 creator A5074731946 @default.
• W2004236535 creator A5082700583 @default.
• W2004236535 date "1998-01-01" @default.
• W2004236535 modified "2023-09-27" @default.
• W2004236535 title "Role of Nitric Oxide on Diaphragmatic Contractile Failure in Escherichia coli Endotoxemic Rats" @default.
• W2004236535 cites W1528220495 @default.
• W2004236535 cites W1747994692 @default.
• W2004236535 cites W1764308599 @default.
• W2004236535 cites W1772163056 @default.
• W2004236535 cites W1799879229 @default.
• W2004236535 cites W1973535328 @default.
• W2004236535 cites W1978140559 @default.
• W2004236535 cites W1979026148 @default.
• W2004236535 cites W1987013989 @default.
• W2004236535 cites W1991299986 @default.
• W2004236535 cites W2001887083 @default.
• W2004236535 cites W2004343006 @default.
• W2004236535 cites W2005952042 @default.
• W2004236535 cites W2009194142 @default.
• W2004236535 cites W2010469212 @default.
• W2004236535 cites W2013069817 @default.
• W2004236535 cites W2017844141 @default.
• W2004236535 cites W2019814232 @default.
• W2004236535 cites W2038633432 @default.
• W2004236535 cites W2048990297 @default.
• W2004236535 cites W2054510493 @default.
• W2004236535 cites W2056761641 @default.
• W2004236535 cites W2058137293 @default.
• W2004236535 cites W2059379142 @default.
• W2004236535 cites W2061381731 @default.
• W2004236535 cites W2065083920 @default.
• W2004236535 cites W2074618658 @default.
• W2004236535 cites W2076473892 @default.
• W2004236535 cites W2077969074 @default.
• W2004236535 cites W2078587014 @default.
• W2004236535 cites W2081759103 @default.
• W2004236535 cites W2090064322 @default.
• W2004236535 cites W2141345678 @default.
• W2004236535 cites W2146070073 @default.
• W2004236535 cites W2151888636 @default.
• W2004236535 cites W2158272509 @default.
• W2004236535 cites W2163314286 @default.
• W2004236535 cites W2243722387 @default.
• W2004236535 cites W2313326603 @default.
• W2004236535 cites W2319407182 @default.
• W2004236535 cites W2334629896 @default.
• W2004236535 cites W2337950398 @default.
• W2004236535 cites W2346447342 @default.
• W2004236535 cites W2415264285 @default.
• W2004236535 cites W2416695692 @default.
• W2004236535 cites W2460101270 @default.
• W2004236535 doi "https://doi.org/10.1016/s1095-6433(97)00422-4" @default.
• W2004236535 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11253781" @default.
• W2004236535 hasPublicationYear "1998" @default.
• W2004236535 type Work @default.
• W2004236535 sameAs 2004236535 @default.
• W2004236535 citedByCount "22" @default.
• W2004236535 countsByYear W20042365352015 @default.
• W2004236535 countsByYear W20042365352017 @default.
• W2004236535 crossrefType "journal-article" @default.
• W2004236535 hasAuthorship W2004236535A5007216227 @default.
• W2004236535 hasAuthorship W2004236535A5013821654 @default.
• W2004236535 hasAuthorship W2004236535A5023687827 @default.
• W2004236535 hasAuthorship W2004236535A5032875267 @default.
• W2004236535 hasAuthorship W2004236535A5051055282 @default.
• W2004236535 hasAuthorship W2004236535A5074731946 @default.
• W2004236535 hasAuthorship W2004236535A5082700583 @default.
• W2004236535 hasConcept C104317684 @default.
• W2004236535 hasConcept C126322002 @default.
• W2004236535 hasConcept C134018914 @default.
• W2004236535 hasConcept C142724271 @default.
• W2004236535 hasConcept C185592680 @default.
• W2004236535 hasConcept C20463939 @default.
• W2004236535 hasConcept C204787440 @default.
• W2004236535 hasConcept C2777468819 @default.
• W2004236535 hasConcept C2777622882 @default.
• W2004236535 hasConcept C2778384902 @default.
• W2004236535 hasConcept C2778754761 @default.
• W2004236535 hasConcept C2779129087 @default.
• W2004236535 hasConcept C515207424 @default.
• W2004236535 hasConcept C519581460 @default.
• W2004236535 hasConcept C547475151 @default.
• W2004236535 hasConcept C55493867 @default.
• W2004236535 hasConcept C71924100 @default.
• W2004236535 hasConcept C86803240 @default.
• W2004236535 hasConceptScore W2004236535C104317684 @default.
• W2004236535 hasConceptScore W2004236535C126322002 @default.
• W2004236535 hasConceptScore W2004236535C134018914 @default.
• W2004236535 hasConceptScore W2004236535C142724271 @default.
• W2004236535 hasConceptScore W2004236535C185592680 @default.
• W2004236535 hasConceptScore W2004236535C20463939 @default.

• next