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- W2004237316 abstract "A rapid and reliable micro procedure for the high pressure liquid chromatographic analysis of cimetidine. N-cyano-N-methyl-N'-[2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]ethyl]guanidine, in serum or plasma is described. The percentage analytical recovery of cimetidine and internal standard (beta-hydroxypropyl-theophylline) was 65 and 99%, respectively. The between-day precision of the method at cimetidine serum concentrations of 2,000, 1,000, and 500 microgram/liter yielded coefficients of variation of 10.6, 11.5, and 10.6%, respectively. The method has been used in preliminary studies to determine the serum concentrations in patients receiving the drug by both the oral and intravenous route." @default.
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- W2004237316 date "1979-01-01" @default.
- W2004237316 modified "2023-10-14" @default.
- W2004237316 title "High Performance Liquid Chromatographic Analysis of Cimetidine in Serum" @default.
- W2004237316 doi "https://doi.org/10.1097/00007691-197901030-00010" @default.
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