FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004237375> ?p ?o ?g. }

• W2004237375 endingPage "399" @default.
• W2004237375 startingPage "391" @default.
• W2004237375 abstract "Zinc may be a limiting factor in restricting catch-up growth in severely malnourished children. This study had two aims: (i) to examine the effect of different zinc supplementation regimens on IGF-I, its binding proteins and on markers of bone and collagen turnover in severely malnourished children and (ii) to investigate mechanisms underlying catch-up growth by examining changes in these markers during nutritional rehabilitation, their inter-relationships and their relationships with ponderal and linear growth.Double-blind randomized intervention study of three regimens of oral zinc supplementation.One hundred and forty-one children, aged 6-36 months, mean (SD) age 15.4 (8.7) months, with day 1 weight-for-height SD score (whz) -2.6 (0.93) and height-for-age SD score (haz) -3.79 (1.29).Weight, height, lower leg length (by knemometry) at 15-day intervals from day 1 to day 90 of nutritional rehabilitation. Blood collection on days 1, 15 and 30 for IGF-I, IGFBP3, IGFBP2, bone alkaline phosphatase (BAP, osteoblast marker), procollagen type I C-terminal propeptide (PICP, marker of type I collagen synthesis), procollagen type III N-terminal propeptide (P3NP, marker of soft tissue type III collagen synthesis) and type I collagen telopeptide (ICTP, marker of type I collagen breakdown).There was early rapid weight gain during refeeding, whereas height gain occurred later in the trial. IGF-I, IGFBP3, BAP, PICP and P3NP were low or very low on day 1 compared to well-nourished age-matched European children, and all increased within 15 days (P < 0.001), with PICP and P3NP reaching levels higher than European norms. IGFBP2 and ICTP were high on day 1 and decreased over the same period (P < 0.001). There were no differences in anthropometric outcome or marker responses among zinc regimens. Day 1 whz was correlated with BAP, PICP and P3NP (P < 0.001). Changes in IGF-I, IGFBP3, BAP, PICP and P3NP over 30 days correlated with ponderal growth (whz change) over the same period (all P < 0.01). However, changes in these markers over 30 days correlated better with lower leg growth (all P < 0.01) and linear growth (haz change, P < 0.01 for PICP and P3NP, P < 0.05 for IGFBP3) measured over 90 compared with 30 days. At most time points, there were strong positive correlations (i) among IGF-I, IGFBP3, BAP, PICP and P3NP (P < 0.01) and (ii) between IGFBP2 and ICTP (P < 0.01). Conversely, IGFBP2 was negatively correlated with IGF-I, IGFBP3, BAP, PICP and P3NP at most time points (P < 0.01).We found no difference among zinc regimens in growth, IGF-I and its binding proteins or markers of bone and collagen turnover. Severe malnutrition was associated with low rates of bone and collagen synthesis and high rates of collagen degradation, and nutritional rehabilitation was associated with full or partial 'normalization' of the markers studied. Early weight gain and subsequent linear growth were associated with early increments in IGF-I, IGFBP3 and markers of bone and collagen formation. The study of these markers has provided additional insights into the mechanisms of the effects of malnutrition and refeeding on growth." @default.
• W2004237375 created "2016-06-24" @default.
• W2004237375 creator A5024391984 @default.
• W2004237375 creator A5026290327 @default.
• W2004237375 creator A5028202624 @default.
• W2004237375 creator A5036483515 @default.
• W2004237375 creator A5038570653 @default.
• W2004237375 creator A5049852391 @default.
• W2004237375 creator A5057376832 @default.
• W2004237375 creator A5085030460 @default.
• W2004237375 creator A5090448936 @default.
• W2004237375 date "2002-08-30" @default.
• W2004237375 modified "2023-10-18" @default.
• W2004237375 title "Malnutrition, zinc supplementation and catch-up growth: changes in insulin-like growth factor I, its binding proteins, bone formation and collagen turnover" @default.
• W2004237375 cites W1495180313 @default.
• W2004237375 cites W1826148855 @default.
• W2004237375 cites W1977372250 @default.
• W2004237375 cites W1978041015 @default.
• W2004237375 cites W1983230888 @default.
• W2004237375 cites W2007962104 @default.
• W2004237375 cites W2008372867 @default.
• W2004237375 cites W2030795608 @default.
• W2004237375 cites W2048504899 @default.
• W2004237375 cites W2053429397 @default.
• W2004237375 cites W2055397849 @default.
• W2004237375 cites W2075940788 @default.
• W2004237375 cites W2081644105 @default.
• W2004237375 cites W2122676071 @default.
• W2004237375 cites W2156116384 @default.
• W2004237375 cites W2171145028 @default.
• W2004237375 cites W2414443518 @default.
• W2004237375 cites W2886164718 @default.
• W2004237375 cites W4243300398 @default.
• W2004237375 cites W2012260656 @default.
• W2004237375 doi "https://doi.org/10.1046/j.1365-2265.2002.01622.x" @default.
• W2004237375 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12201833" @default.
• W2004237375 hasPublicationYear "2002" @default.
• W2004237375 type Work @default.
• W2004237375 sameAs 2004237375 @default.
• W2004237375 citedByCount "37" @default.
• W2004237375 countsByYear W20042373752012 @default.
• W2004237375 countsByYear W20042373752013 @default.
• W2004237375 countsByYear W20042373752014 @default.
• W2004237375 countsByYear W20042373752015 @default.
• W2004237375 countsByYear W20042373752016 @default.
• W2004237375 countsByYear W20042373752017 @default.
• W2004237375 countsByYear W20042373752018 @default.
• W2004237375 countsByYear W20042373752019 @default.
• W2004237375 countsByYear W20042373752022 @default.
• W2004237375 countsByYear W20042373752023 @default.
• W2004237375 crossrefType "journal-article" @default.
• W2004237375 hasAuthorship W2004237375A5024391984 @default.
• W2004237375 hasAuthorship W2004237375A5026290327 @default.
• W2004237375 hasAuthorship W2004237375A5028202624 @default.
• W2004237375 hasAuthorship W2004237375A5036483515 @default.
• W2004237375 hasAuthorship W2004237375A5038570653 @default.
• W2004237375 hasAuthorship W2004237375A5049852391 @default.
• W2004237375 hasAuthorship W2004237375A5057376832 @default.
• W2004237375 hasAuthorship W2004237375A5085030460 @default.
• W2004237375 hasAuthorship W2004237375A5090448936 @default.
• W2004237375 hasConcept C125870589 @default.
• W2004237375 hasConcept C126322002 @default.
• W2004237375 hasConcept C131075544 @default.
• W2004237375 hasConcept C134018914 @default.
• W2004237375 hasConcept C160160445 @default.
• W2004237375 hasConcept C170033053 @default.
• W2004237375 hasConcept C170493617 @default.
• W2004237375 hasConcept C181199279 @default.
• W2004237375 hasConcept C2775960820 @default.
• W2004237375 hasConcept C2778279177 @default.
• W2004237375 hasConcept C2780644872 @default.
• W2004237375 hasConcept C2780689927 @default.
• W2004237375 hasConcept C55493867 @default.
• W2004237375 hasConcept C64348721 @default.
• W2004237375 hasConcept C71924100 @default.
• W2004237375 hasConcept C86803240 @default.
• W2004237375 hasConceptScore W2004237375C125870589 @default.
• W2004237375 hasConceptScore W2004237375C126322002 @default.
• W2004237375 hasConceptScore W2004237375C131075544 @default.
• W2004237375 hasConceptScore W2004237375C134018914 @default.
• W2004237375 hasConceptScore W2004237375C160160445 @default.
• W2004237375 hasConceptScore W2004237375C170033053 @default.
• W2004237375 hasConceptScore W2004237375C170493617 @default.
• W2004237375 hasConceptScore W2004237375C181199279 @default.
• W2004237375 hasConceptScore W2004237375C2775960820 @default.
• W2004237375 hasConceptScore W2004237375C2778279177 @default.
• W2004237375 hasConceptScore W2004237375C2780644872 @default.
• W2004237375 hasConceptScore W2004237375C2780689927 @default.
• W2004237375 hasConceptScore W2004237375C55493867 @default.
• W2004237375 hasConceptScore W2004237375C64348721 @default.
• W2004237375 hasConceptScore W2004237375C71924100 @default.
• W2004237375 hasConceptScore W2004237375C86803240 @default.
• W2004237375 hasIssue "3" @default.
• W2004237375 hasLocation W20042373751 @default.
• W2004237375 hasLocation W20042373752 @default.
• W2004237375 hasOpenAccess W2004237375 @default.
• W2004237375 hasPrimaryLocation W20042373751 @default.
• W2004237375 hasRelatedWork W1965454498 @default.

• next