Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004237567> ?p ?o ?g. }
- W2004237567 endingPage "933" @default.
- W2004237567 startingPage "924" @default.
- W2004237567 abstract "As the threshold nucleated cell dose for one-unit umbilical cord blood (UCB) in adults has not to date been firmly established, we prospectively compared one- vs two-unit UCB transplantation after reduced intensity conditioning (RIC) in adult patients with hematological malignancies. Study design specified one-UCB unit if the cryopreserved total nucleated cell (TNC) dose was ⩾2.5 × 107/kg recipient weight, otherwise two units matched at minima of 4/6 HLA loci to the patient and 3/6 to each other were infused. A total of 27 patients received one unit; 23 patients received two units. Median time to ANC >500/μL was 24 days (95% confidence interval 22–28 days), 25 days for one unit and 23 days for two units (P=0.99). At day 100, ANC >500/μL was 88.4 and 91.3% in the one- and two-unit groups (P=0.99), respectively. Three-year EFS was 28.6% and 39.1% in the one- and two-unit groups (P=0.71), respectively. Infusion of two units was associated with a significantly lower relapse risk, 30.4% vs 59.3% (P=0.045). Infused cell doses (TNC, CD3+, CD34+ and CD56+CD3neg) did not impact on engraftment, OS or EFS. Taken together, one-unit UCB transplantation with a threshold cell dose ⩾2.5 × 107/kg recipient weight after RIC is a viable option for adults, although infusion of two units confers a lower relapse incidence." @default.
- W2004237567 created "2016-06-24" @default.
- W2004237567 creator A5006142419 @default.
- W2004237567 creator A5013116738 @default.
- W2004237567 creator A5013926915 @default.
- W2004237567 creator A5019470085 @default.
- W2004237567 creator A5020119243 @default.
- W2004237567 creator A5030498870 @default.
- W2004237567 creator A5037772762 @default.
- W2004237567 creator A5038075213 @default.
- W2004237567 creator A5042915360 @default.
- W2004237567 creator A5045231164 @default.
- W2004237567 creator A5055100327 @default.
- W2004237567 creator A5059061070 @default.
- W2004237567 creator A5059783665 @default.
- W2004237567 creator A5059797628 @default.
- W2004237567 creator A5059965048 @default.
- W2004237567 creator A5061885005 @default.
- W2004237567 date "2011-10-17" @default.
- W2004237567 modified "2023-10-15" @default.
- W2004237567 title "Prospective study of one- vs two-unit umbilical cord blood transplantation following reduced intensity conditioning in adults with hematological malignancies" @default.
- W2004237567 cites W113410267 @default.
- W2004237567 cites W1485136427 @default.
- W2004237567 cites W1598652831 @default.
- W2004237567 cites W1965359675 @default.
- W2004237567 cites W1965613868 @default.
- W2004237567 cites W1966154522 @default.
- W2004237567 cites W1966635335 @default.
- W2004237567 cites W1967489538 @default.
- W2004237567 cites W1969096688 @default.
- W2004237567 cites W1970812781 @default.
- W2004237567 cites W1973336051 @default.
- W2004237567 cites W1973881356 @default.
- W2004237567 cites W1975771741 @default.
- W2004237567 cites W1987385616 @default.
- W2004237567 cites W1991399630 @default.
- W2004237567 cites W2011561948 @default.
- W2004237567 cites W2018953748 @default.
- W2004237567 cites W2019481459 @default.
- W2004237567 cites W2028795322 @default.
- W2004237567 cites W2032458212 @default.
- W2004237567 cites W2034333555 @default.
- W2004237567 cites W2034375556 @default.
- W2004237567 cites W2037127770 @default.
- W2004237567 cites W2039964265 @default.
- W2004237567 cites W2060850302 @default.
- W2004237567 cites W2063931050 @default.
- W2004237567 cites W2066816406 @default.
- W2004237567 cites W2079023050 @default.
- W2004237567 cites W2081949521 @default.
- W2004237567 cites W2086101504 @default.
- W2004237567 cites W2089832972 @default.
- W2004237567 cites W2098668249 @default.
- W2004237567 cites W2099847697 @default.
- W2004237567 cites W2104711659 @default.
- W2004237567 cites W2106578604 @default.
- W2004237567 cites W2111558234 @default.
- W2004237567 cites W2114342114 @default.
- W2004237567 cites W2122469298 @default.
- W2004237567 cites W2128406628 @default.
- W2004237567 cites W2135067231 @default.
- W2004237567 cites W2136590050 @default.
- W2004237567 cites W2141557403 @default.
- W2004237567 cites W2151140601 @default.
- W2004237567 cites W2153021079 @default.
- W2004237567 cites W2168842377 @default.
- W2004237567 doi "https://doi.org/10.1038/bmt.2011.195" @default.
- W2004237567 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3262108" @default.
- W2004237567 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22002488" @default.
- W2004237567 hasPublicationYear "2011" @default.
- W2004237567 type Work @default.
- W2004237567 sameAs 2004237567 @default.
- W2004237567 citedByCount "56" @default.
- W2004237567 countsByYear W20042375672012 @default.
- W2004237567 countsByYear W20042375672013 @default.
- W2004237567 countsByYear W20042375672014 @default.
- W2004237567 countsByYear W20042375672015 @default.
- W2004237567 countsByYear W20042375672016 @default.
- W2004237567 countsByYear W20042375672017 @default.
- W2004237567 countsByYear W20042375672018 @default.
- W2004237567 countsByYear W20042375672019 @default.
- W2004237567 countsByYear W20042375672021 @default.
- W2004237567 countsByYear W20042375672022 @default.
- W2004237567 countsByYear W20042375672023 @default.
- W2004237567 crossrefType "journal-article" @default.
- W2004237567 hasAuthorship W2004237567A5006142419 @default.
- W2004237567 hasAuthorship W2004237567A5013116738 @default.
- W2004237567 hasAuthorship W2004237567A5013926915 @default.
- W2004237567 hasAuthorship W2004237567A5019470085 @default.
- W2004237567 hasAuthorship W2004237567A5020119243 @default.
- W2004237567 hasAuthorship W2004237567A5030498870 @default.
- W2004237567 hasAuthorship W2004237567A5037772762 @default.
- W2004237567 hasAuthorship W2004237567A5038075213 @default.
- W2004237567 hasAuthorship W2004237567A5042915360 @default.
- W2004237567 hasAuthorship W2004237567A5045231164 @default.
- W2004237567 hasAuthorship W2004237567A5055100327 @default.
- W2004237567 hasAuthorship W2004237567A5059061070 @default.
- W2004237567 hasAuthorship W2004237567A5059783665 @default.