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- W2004238936 abstract "It has long been suspected that sensory signal transmission is inhibited in the mammalian brain during sleep. We hypothesized that Ca v 3.1 T-type Ca 2+ channel currents inhibit thalamic sensory transmission to promote sleep. We found that T-type Ca 2+ channel activation caused prolonged inhibition (>9 s) of action-potential firing in thalamic projection neurons of WT but not Ca v 3.1 knockout mice. Inhibition occurred with synaptic transmission blocked and required an increase of intracellular Ca 2+ . Furthermore, focal deletion of the gene encoding Ca v 3.1 from the rostral–midline thalamus by using Cre/ loxP recombination led to frequent and prolonged arousal, which fragmented and reduced sleep. Interestingly, sleep was not disturbed when Ca v 3.1 was deleted from cortical pyramidal neurons. These findings support the hypothesis that thalamic T-type Ca 2+ channels are required to block transmission of arousal signals through the thalamus and to stabilize sleep." @default.
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- W2004238936 date "2005-01-26" @default.
- W2004238936 modified "2023-10-06" @default.
- W2004238936 title "Thalamic Ca <sub>v</sub> 3.1 T-type Ca <sup>2</sup> + channel plays a crucial role in stabilizing sleep" @default.
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- W2004238936 doi "https://doi.org/10.1073/pnas.0409644102" @default.
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