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- W2004240007 abstract "We investigated the effects of KW-3902 (8-(noradamantan-3-yl)-1,3-dipropylxanthine), a potent adenosine A1-receptor antagonist, on the nephrotic edema induced by puromycin aminonucleoside (PAN; 100 mg/kg, i.v.) in rats. The treatment with PAN decreased urine volume and urinary excretions of sodium and potassium, resulting in the ascites formation in 7 days. In rats with the nephrosis, KW-3902 (0.01-1 mg/kg/day for 3 days, p.o.) showed diuretic effects and reduced the volume of ascites, as was the case with furosemide (30 mg/kg/day) and trichlormethiazide (1 mg/kg/day). These results suggest that even in the nephrotic state, the adenosine A1-receptor antagonist can be an effective diuretic to ameliorate edema." @default.
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- W2004240007 date "1995-01-01" @default.
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- W2004240007 title "Effects of KW-3902, an Adenosine A1-Receptor Antagonist, on Ascites Volume in Puromycin Aminonucleoside (PAN)-Induced Nephrotic Rats" @default.
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- W2004240007 doi "https://doi.org/10.1254/jjp.68.213" @default.
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