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- W2004240626 abstract "Serotonin (5-HT) may act during development as a neurotrophic agent. Evidence suggests that sexually dimorphic regions of the mammalian nervous system (which often possess sexually dimorphic patterns of 5-HT innervation) could provide a model for this aspect of 5-HT action. Albino Swiss rat pups were treated with p-chlorophenyl alanine (pCPA, 200 mg/kg) or 5-hydroxytryptophan (5-HTP, 75 mg/kg) for 14 days after birth. As adults, the number of motor neurons in the sexually dimorphic spinal nucleus of bulbocavernosus (SNB) and dorsolateral nucleus (DLN), together with the non-dimorphic ventromedial nucleus (VM) were analysed. Postnatal treatment with 5-HTP had a general effect of increasing motor neuron numbers in all three groups. However, pCPA treatment had a marked and specific effect on SNB neuron numbers, increasing these in both sexes (+250% in females and +60% in males) compared with control animals. The results suggest that the postnatal innervation of ventral horn motor neurons by 5-HT-containing terminals may affect cell death at this time." @default.
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- W2004240626 date "1992-03-01" @default.
- W2004240626 modified "2023-09-25" @default.
- W2004240626 title "The effects of serotonin manipulation during the postnatal period on the development of sexually dimorphic and non-dimorphic lumbosacral motor neuron groups in the albino Swiss rat" @default.
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- W2004240626 doi "https://doi.org/10.1016/0165-3806(92)90140-r" @default.
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