FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004241870> ?p ?o ?g. }

• W2004241870 endingPage "790" @default.
• W2004241870 startingPage "785" @default.
• W2004241870 abstract "Interleukin 1 (IL-1) plays a central role in the regulation of the body's response to infectious and inflammatory stimuli. Recent evidence has shown that human platelets express a cell associated form of this proinflammatory cytokine very rapidly following activation. Since one of the earliest events in inflammation is frequently the rapid adhesion of platelets to injured endothelium, it was of interest to determine whether platelets express IL-1 in a functionally relevant form that can alter the phenotype of human endothelial cells in vitro. Thrombin activated platelets induced significant expression of the adhesion molecule intercellular adhesion molecule 1, as well as secretion of the IL-1 inducible cytokines IL-6 and granulocyte macrophage colony stimulating factor by cultured human umbilical cord and saphenous vein endothelial cells. This was inhibited by prior treatment of the platelets with antibody specific for IL-1. These results suggest that platelet delivered IL-1 might initiate and regulate some of the earliest phases of the inflammatory response. An additional observation of interest was differential induction of endothelial leucocyte adhesion molecule 1 by activated platelets on saphenous vein but not umbilical vein but not umbilical vein endothelial cells, which suggests functional heterogeneity of the endothelial cells." @default.
• W2004241870 created "2016-06-24" @default.
• W2004241870 creator A5002595354 @default.
• W2004241870 creator A5007679547 @default.
• W2004241870 creator A5057580992 @default.
• W2004241870 date "1991-10-01" @default.
• W2004241870 modified "2023-09-26" @default.
• W2004241870 title "Platelet-derived interleukin 1 induces human endothelial adhesion molecule expression and cytokine production." @default.
• W2004241870 cites W1570440286 @default.
• W2004241870 cites W1773738593 @default.
• W2004241870 cites W1966286149 @default.
• W2004241870 cites W1973312218 @default.
• W2004241870 cites W1997324943 @default.
• W2004241870 cites W2002639359 @default.
• W2004241870 cites W2008183740 @default.
• W2004241870 cites W2013993175 @default.
• W2004241870 cites W2026075546 @default.
• W2004241870 cites W2029432061 @default.
• W2004241870 cites W2073184870 @default.
• W2004241870 cites W2081596799 @default.
• W2004241870 cites W2091464556 @default.
• W2004241870 cites W2100994529 @default.
• W2004241870 cites W2103242703 @default.
• W2004241870 cites W2213793608 @default.
• W2004241870 cites W2399818948 @default.
• W2004241870 cites W2417515699 @default.
• W2004241870 cites W2470229176 @default.
• W2004241870 doi "https://doi.org/10.1084/jem.174.4.785" @default.
• W2004241870 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2118954" @default.
• W2004241870 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1680957" @default.
• W2004241870 hasPublicationYear "1991" @default.
• W2004241870 type Work @default.
• W2004241870 sameAs 2004241870 @default.
• W2004241870 citedByCount "195" @default.
• W2004241870 countsByYear W20042418702012 @default.
• W2004241870 countsByYear W20042418702013 @default.
• W2004241870 countsByYear W20042418702014 @default.
• W2004241870 countsByYear W20042418702015 @default.
• W2004241870 countsByYear W20042418702016 @default.
• W2004241870 countsByYear W20042418702017 @default.
• W2004241870 countsByYear W20042418702018 @default.
• W2004241870 countsByYear W20042418702019 @default.
• W2004241870 countsByYear W20042418702020 @default.
• W2004241870 countsByYear W20042418702021 @default.
• W2004241870 countsByYear W20042418702022 @default.
• W2004241870 countsByYear W20042418702023 @default.
• W2004241870 crossrefType "journal-article" @default.
• W2004241870 hasAuthorship W2004241870A5002595354 @default.
• W2004241870 hasAuthorship W2004241870A5007679547 @default.
• W2004241870 hasAuthorship W2004241870A5057580992 @default.
• W2004241870 hasBestOaLocation W20042418701 @default.
• W2004241870 hasConcept C123012128 @default.
• W2004241870 hasConcept C132155493 @default.
• W2004241870 hasConcept C134018914 @default.
• W2004241870 hasConcept C1491633281 @default.
• W2004241870 hasConcept C16224149 @default.
• W2004241870 hasConcept C164027704 @default.
• W2004241870 hasConcept C202751555 @default.
• W2004241870 hasConcept C203014093 @default.
• W2004241870 hasConcept C2776914184 @default.
• W2004241870 hasConcept C2776992346 @default.
• W2004241870 hasConcept C2777292125 @default.
• W2004241870 hasConcept C2777411675 @default.
• W2004241870 hasConcept C2778690821 @default.
• W2004241870 hasConcept C3018697912 @default.
• W2004241870 hasConcept C55493867 @default.
• W2004241870 hasConcept C85789140 @default.
• W2004241870 hasConcept C86803240 @default.
• W2004241870 hasConcept C89560881 @default.
• W2004241870 hasConcept C95444343 @default.
• W2004241870 hasConceptScore W2004241870C123012128 @default.
• W2004241870 hasConceptScore W2004241870C132155493 @default.
• W2004241870 hasConceptScore W2004241870C134018914 @default.
• W2004241870 hasConceptScore W2004241870C1491633281 @default.
• W2004241870 hasConceptScore W2004241870C16224149 @default.
• W2004241870 hasConceptScore W2004241870C164027704 @default.
• W2004241870 hasConceptScore W2004241870C202751555 @default.
• W2004241870 hasConceptScore W2004241870C203014093 @default.
• W2004241870 hasConceptScore W2004241870C2776914184 @default.
• W2004241870 hasConceptScore W2004241870C2776992346 @default.
• W2004241870 hasConceptScore W2004241870C2777292125 @default.
• W2004241870 hasConceptScore W2004241870C2777411675 @default.
• W2004241870 hasConceptScore W2004241870C2778690821 @default.
• W2004241870 hasConceptScore W2004241870C3018697912 @default.
• W2004241870 hasConceptScore W2004241870C55493867 @default.
• W2004241870 hasConceptScore W2004241870C85789140 @default.
• W2004241870 hasConceptScore W2004241870C86803240 @default.
• W2004241870 hasConceptScore W2004241870C89560881 @default.
• W2004241870 hasConceptScore W2004241870C95444343 @default.
• W2004241870 hasIssue "4" @default.
• W2004241870 hasLocation W20042418701 @default.
• W2004241870 hasLocation W20042418702 @default.
• W2004241870 hasLocation W20042418703 @default.
• W2004241870 hasLocation W20042418704 @default.
• W2004241870 hasOpenAccess W2004241870 @default.
• W2004241870 hasPrimaryLocation W20042418701 @default.
• W2004241870 hasRelatedWork W1486844399 @default.
• W2004241870 hasRelatedWork W1995832396 @default.

• next