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- W2004246159 abstract "Serotonin lesioning studies were performed to determine the synaptic localization of the 5-HT1D receptor. Four days following p-chloroamphetamine (PCA; 5 mg/kg x 4) [3H]paroxetine-labeled uptake sites (a marker for 5-HT terminals) were reduced to 18% of control values in the cortex and 29% of control values in the striatum, while the number of 5-HT1D receptors remained unchanged. Fourteen days following PCA administration an up-regulation of cortical 5-HT1D receptors was observed. These findings indicate that 5-HT1D receptors are localized postsynaptically in the cortex and striatum, and that denervation of endogenous serotonergic input produces a compensatory up-regulation in the cortex." @default.
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- W2004246159 date "1989-03-01" @default.
- W2004246159 modified "2023-09-26" @default.
- W2004246159 title "Postsynaptic localization and up-regulation of serotonin 5-HT1D receptors in rat brain" @default.
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- W2004246159 doi "https://doi.org/10.1016/0006-8993(89)90047-4" @default.
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