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- W2004248171 abstract "Phorbol 12,13-dibutyrate (PDBu) was employed in studies designed to determine the role of C-kinase in muscle contraction in the iris sphincter. PDBu induced MLC phosphorylation and contraction in a dose- and time-dependent manner. Maximum responses exerted by PDBu were about 50–60% of that obtained with CCh, and were totally dependent on the presence of extracellular Ca2+. PDBu had no effect on basal IP3 levels, however it blocked the CCh-stimulated accumulation of IP3. PDBu-induced effects were potentiated by ionomycin, and inhibited by the C-kinase antagonist H-7. These results provide further evidence for the involvement of C-kinase in mediating the sustained phase of the contractile response in the iris sphincter." @default.
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- W2004248171 title "Phorbol ester-induced protein phosphorylation and contraction in sphincter smooth muscle of rabbit iris" @default.
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- W2004248171 doi "https://doi.org/10.1016/0014-5793(87)80162-x" @default.
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