FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004248238> ?p ?o ?g. }

• W2004248238 endingPage "1947" @default.
• W2004248238 startingPage "1947" @default.
• W2004248238 abstract "The elderly produce increased levels of antibodies to autologous antigens and are less able to make high-affinity antibodies to foreign antigens. Ig gene hypermutation is integral to the affinity maturation process but previous studies of hypermutation with age have yielded conflicting results. The cells studied have represented post-germinal center (GC) populations and, therefore, the results may be complicated by possible differences in activation history. We studied Ig genes from GC B cells to elucidate which factors in the affinity maturation process change with age. Age-related changes in the pattern of hypermutation were seen, although the analysis of variable region heavy chain (VH) genes and their lineage trees shows that an alteration in the mechanism of somatic hypermutation is unlikely. The changes are due to founder cell effects and/or the process of selection. Striking tissue-specific differences were seen. All measurements indicated that selection of Ig genes may decrease in Peyer's patch GC but increase in splenic GC with age. These tissue-specific differences highlight the importance of considering the activation and effector sites when studying immune senescence." @default.
• W2004248238 created "2016-06-24" @default.
• W2004248238 creator A5040094072 @default.
• W2004248238 creator A5049645038 @default.
• W2004248238 creator A5062389128 @default.
• W2004248238 creator A5063110419 @default.
• W2004248238 creator A5064643031 @default.
• W2004248238 date "2002-07-01" @default.
• W2004248238 modified "2023-09-26" @default.
• W2004248238 title "Age- and tissue-specific differences in human germinal center B cell selection revealed by analysis of IgVH gene hypermutation and lineage trees" @default.
• W2004248238 cites W1505394912 @default.
• W2004248238 cites W1518159864 @default.
• W2004248238 cites W1532951345 @default.
• W2004248238 cites W1577104641 @default.
• W2004248238 cites W1578803305 @default.
• W2004248238 cites W1590538302 @default.
• W2004248238 cites W16064511 @default.
• W2004248238 cites W1969881232 @default.
• W2004248238 cites W1971344703 @default.
• W2004248238 cites W1979617802 @default.
• W2004248238 cites W1982216444 @default.
• W2004248238 cites W1987750593 @default.
• W2004248238 cites W1991799493 @default.
• W2004248238 cites W2000106165 @default.
• W2004248238 cites W2005566446 @default.
• W2004248238 cites W2009127800 @default.
• W2004248238 cites W2013628600 @default.
• W2004248238 cites W2030816309 @default.
• W2004248238 cites W2034094261 @default.
• W2004248238 cites W2034659547 @default.
• W2004248238 cites W2036426716 @default.
• W2004248238 cites W2043464691 @default.
• W2004248238 cites W2046263243 @default.
• W2004248238 cites W2056583190 @default.
• W2004248238 cites W2060896000 @default.
• W2004248238 cites W2064711508 @default.
• W2004248238 cites W2068239797 @default.
• W2004248238 cites W2069772361 @default.
• W2004248238 cites W2084857996 @default.
• W2004248238 cites W2091067968 @default.
• W2004248238 cites W2091974060 @default.
• W2004248238 cites W2113078618 @default.
• W2004248238 cites W2116447401 @default.
• W2004248238 cites W2142933472 @default.
• W2004248238 doi "https://doi.org/10.1002/1521-4141(200207)32:7<1947::aid-immu1947>3.0.co;2-1" @default.
• W2004248238 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12115615" @default.
• W2004248238 hasPublicationYear "2002" @default.
• W2004248238 type Work @default.
• W2004248238 sameAs 2004248238 @default.
• W2004248238 citedByCount "85" @default.
• W2004248238 countsByYear W20042482382012 @default.
• W2004248238 countsByYear W20042482382013 @default.
• W2004248238 countsByYear W20042482382014 @default.
• W2004248238 countsByYear W20042482382015 @default.
• W2004248238 countsByYear W20042482382016 @default.
• W2004248238 countsByYear W20042482382017 @default.
• W2004248238 countsByYear W20042482382018 @default.
• W2004248238 countsByYear W20042482382019 @default.
• W2004248238 countsByYear W20042482382020 @default.
• W2004248238 countsByYear W20042482382021 @default.
• W2004248238 countsByYear W20042482382022 @default.
• W2004248238 countsByYear W20042482382023 @default.
• W2004248238 crossrefType "journal-article" @default.
• W2004248238 hasAuthorship W2004248238A5040094072 @default.
• W2004248238 hasAuthorship W2004248238A5049645038 @default.
• W2004248238 hasAuthorship W2004248238A5062389128 @default.
• W2004248238 hasAuthorship W2004248238A5063110419 @default.
• W2004248238 hasAuthorship W2004248238A5064643031 @default.
• W2004248238 hasBestOaLocation W20042482381 @default.
• W2004248238 hasConcept C104317684 @default.
• W2004248238 hasConcept C128526571 @default.
• W2004248238 hasConcept C159654299 @default.
• W2004248238 hasConcept C203014093 @default.
• W2004248238 hasConcept C2776817793 @default.
• W2004248238 hasConcept C2778453870 @default.
• W2004248238 hasConcept C2781377902 @default.
• W2004248238 hasConcept C522857546 @default.
• W2004248238 hasConcept C54355233 @default.
• W2004248238 hasConcept C86803240 @default.
• W2004248238 hasConcept C95444343 @default.
• W2004248238 hasConcept C96926380 @default.
• W2004248238 hasConceptScore W2004248238C104317684 @default.
• W2004248238 hasConceptScore W2004248238C128526571 @default.
• W2004248238 hasConceptScore W2004248238C159654299 @default.
• W2004248238 hasConceptScore W2004248238C203014093 @default.
• W2004248238 hasConceptScore W2004248238C2776817793 @default.
• W2004248238 hasConceptScore W2004248238C2778453870 @default.
• W2004248238 hasConceptScore W2004248238C2781377902 @default.
• W2004248238 hasConceptScore W2004248238C522857546 @default.
• W2004248238 hasConceptScore W2004248238C54355233 @default.
• W2004248238 hasConceptScore W2004248238C86803240 @default.
• W2004248238 hasConceptScore W2004248238C95444343 @default.
• W2004248238 hasConceptScore W2004248238C96926380 @default.
• W2004248238 hasIssue "7" @default.
• W2004248238 hasLocation W20042482381 @default.
• W2004248238 hasLocation W20042482382 @default.
• W2004248238 hasOpenAccess W2004248238 @default.
• W2004248238 hasPrimaryLocation W20042482381 @default.

• next