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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004250083> ?p ?o ?g. }

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• W2004250083 abstract "<h3>Abstract</h3> Most tissue samples are composed of different cell types. Differential expression analysis without accounting for cell type composition cannot separate the changes due to cell type composition or cell type-specific expression. We propose a computational framework to address these limitations: <b>C</b>ell Type <b>A</b>ware analysis of <b>R</b>NA-<b>seq</b> (CARseq). CARseq employs a negative binomial distribution that appropriately models the count data from RNA-seq experiments. Simulation studies show that CARseq has substantially higher power than a linear model-based approach and it also provides more accurate estimate of the rankings of differentially expressed genes. We have applied CARseq to compare gene expression of schizophrenia/autism subjects versus controls, and identified the cell types underlying the difference and similarities of these two neuron-developmental diseases. Our results are consistent with the results from differential expression analysis using single cell RNA-seq data." @default.
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• W2004250083 date "1982-01-09" @default.
• W2004250083 modified "2023-09-25" @default.
• W2004250083 title "Does the order of second-line treatment in rheumatoid arthritis matter?" @default.
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• W2004250083 doi "https://doi.org/10.1136/bmj.284.6309.79" @default.
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