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• W2004256449 abstract "To identify a new safe antiplasmodial molecular scaffold, an original series of 2-trichloromethylquinazolines, functionalized in position 4 by an alkyl- or arylamino substituent, was synthesized from 4-chloro-2-trichloromethylquinazoline 1, via a cheap, fast and efficient solvent-free operating procedure. Among the 40 molecules prepared, several exhibit a good profile with both a significant antiplasmodial activity on the W2 Plasmodium falciparum strain (IC50 values: 0.4–2.2 μM) and a promising toxicological behavior regarding human cells (HepG2/W2 selectivity indexes: 40–83), compared to the antimalarial drug compounds chloroquine and doxycycline. The in vitro antitoxoplasmic and antileishmanial evaluations were conducted in parallel on the most active molecules, showing that these ones specifically display antiplasmodial properties." @default.
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• W2004256449 date "2009-07-01" @default.
• W2004256449 modified "2023-10-10" @default.
• W2004256449 title "Synthesis and in vitro antiplasmodial evaluation of 4-anilino-2-trichloromethylquinazolines" @default.
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• W2004256449 doi "https://doi.org/10.1016/j.bmc.2009.05.022" @default.
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