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- W2004257946 abstract "Abstract The possible etiologies of sexual maturation have been systematically analyzed in the male rat. The changing patterns of LH and FSH in blood during maturation appear to be explained by changing feedback sensitivity to gonadal steroids and changing response or the pituitary to gonadotropin releasing hormone. The changing responses to GnRH are in turn explained by testosterone modulation at a pituitary level. LH is high in the 10-day-old animal, falls at 20 days, and then steadily increases during maturation. FSH, in contrast, is high at 10 and 20 days and falls progressively as maturation proceeds. Testicular sensitivity or response to LH progressively increases during maturation and appears to be a major factor in increasing testosterone concentrations. Five days following hypophysectomy, the immature male rat shows little or no testosterone secretion in response to large doses or LH. Responsiveness may he restored by pretreatment with FSH. The magnitude or the response appears to be related to the duration of exposure to, as well as the dose of, FSH. FSH appears to induce responsiveness to LH. The mechanism of this induction is uncertain. LH receptor populations do not appear to change during FSH exposure. Thus a major factor in sexual maturation in the male rat appears to be changing sensitivity of the teslis to LH stimulation of testosterone secretion." @default.
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- W2004257946 date "1975-06-01" @default.
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- W2004257946 title "The role of testicular sensitivity to gonadotropins in sexual maturation of the male rat" @default.
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- W2004257946 doi "https://doi.org/10.1016/0022-4731(75)90314-3" @default.
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