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- W2004257973 abstract "Hypertrophic cardiomyopathies (HCM) are often associated with left ventricular (LV) outflow tract obstruction, which can explain symptoms and impact prognosis. To better understand the mechanisms that link obstruction and LV shape in HCM. Patients with HCM who underwent cardiac magnetic resonance (CMR) imaging were included retrospectively. Obstructive HCM was defined as LV outflow gradient more than 30 mmHg at rest by transthoracic echocardiography. The LV shape and mitral angle were assessed by CMR. Results were compared with control subjects. Mean LV-mitral angle was smaller in patients with obstructive HCM (n = 29) than in patients with non-obstructive HCM (n = 15) or control subjects (n = 15) (80 ± 5° vs 87 ± 7° [P = 0.0002] and 89 ± 2° [P < 0.0001]). Mean mitral papillary muscles angle was greater in patients with non-obstructive HCM than in patients with obstructive HCM or control subjects (136 ± 17° vs 123 ± 16° [P = 0.007] and 118 ± 10° [P = 0.002]). Patients with non-obstructive HCM had a greater mean LV-aortic root angle than patients with obstructive HCM or control subjects (139 ± 6° vs 135 ± 7° [P = 0.04] and 133 ± 7° [P = 0.03]). There is a relation between morphological and functional parameters in HCM within which the mitral valve is probably part of pathophysiogenesis. Les cardiomyopathies hypertrophiques (CMH) sont souvent associées à une obstruction intraventriculaire gauche qui peut expliquer les symptômes et modifier le pronostic. Mieux comprendre les mécanismes qui relient l’obstruction intraventriculaire et la géométrie ventriculaire dans la CMH. Les patients porteurs d’une CMH et ayant été explorés par imagerie par résonance magnétique (IRM) cardiaque ont été rétrospectivement inclus. La CMH obstructive était définie par un gradient intraventriculaire gauche supérieur à 30 mmHg au repos en échocardiographie transthoracique. La géométrie ventriculaire gauche et l’angle de la valve mitrale avec le ventricule gauche ont été explorés par IRM. Les résultats ont été comparés à ceux de sujets témoins. L’angle mitral moyen était plus petit chez les patients porteurs d’une CMH obstructive (n = 29) que chez les patients porteurs d’une CMH non obstructive (n = 15) ou chez les sujets témoins (n = 15) (80 ± 5° contre 89 ± 2° [p < 0,0001] et 87 ± 7° [p = 0,0002]). L’angle interpapillaire moyen était plus important chez les patients porteurs d’une CMH non obstructive que chez les patients porteurs d’une CMH obstructive ou chez les sujets témoins (136 ± 17° contre 123 ± 16° [p = 0,007] et 118 ± 10° [p = 0,002]). Les patients porteurs d’une CMH non obstructive avaient un angle aortique moyen plus grand que les patients porteurs d’une CMH obstructive ou que les sujets témoins (139 ± 6° contre 135 ± 7° [p = 0,04] et 133 ± 7° [p = 0,03]). Il existe une relation entre les paramètres morphologiques et fonctionnels du myocarde dans la CMH, dans laquelle la valve mitrale intervient probablement dans la physiopathologie." @default.
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- W2004257973 date "2013-08-01" @default.
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- W2004257973 title "Relation between left ventricular outflow tract obstruction and left ventricular shape in patients with hypertrophic cardiomyopathy: A cardiac magnetic resonance imaging study" @default.
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- W2004257973 doi "https://doi.org/10.1016/j.acvd.2013.05.002" @default.
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