Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004258568> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2004258568 endingPage "1911" @default.
- W2004258568 startingPage "1907" @default.
- W2004258568 abstract "We performed a case-control study to determine whether molecular variants of genes of the renin-angiotensin system were associated with the presence of albuminuria in non-insulin dependent diabetes mellitus (NIDDM). A total of 180 diabetic patients with persistent microalbuminuria [median urinary albumin (interquartile range) of 74 (54 to 126 mg/liter)] were matched with two control groups of diabetic patients without microalbuminuria [median urinary albumin 7 (5 to 10) mg/liter] for variables known to be associated with raised urinary albumin concentration including hemoglobin A1c and triglyceride. One control group was also matched for blood pressure and the other group was not, to allow assessment of interactions with hypertension. Association with the I/D polymorphism of the ACE gene and M235T variant of the angiotensinogen gene (AGT) with microalbuminuria and retinopathy was examined. There were no significant differences in genotype frequency between cases and controls for ACE or AGT irrespective of blood pressure matching. However, among subjects with microalbuminuria, those with the ACE DD genotype had a significantly greater urinary albumin excretion than individuals with a non-DD genotype [median 88 (68 to 170) mg/liter vs. 67 (53 to 113) mg/liter, P < 0.001]. More subjects with the DD than non-DD genotype had persistent albuminuria > 100 mg/liter, twice the upper normal range (60% vs. 38%, P = 0.006). When increased albumin excretion occurs, the presence of the ACE DD genotype appears to be associated with higher urinary albumin levels. No association with retinopathy was observed." @default.
- W2004258568 created "2016-06-24" @default.
- W2004258568 creator A5007719363 @default.
- W2004258568 creator A5013921395 @default.
- W2004258568 creator A5035095307 @default.
- W2004258568 creator A5064727417 @default.
- W2004258568 creator A5086462179 @default.
- W2004258568 date "1995-12-01" @default.
- W2004258568 modified "2023-10-15" @default.
- W2004258568 title "U.K. Prospective Diabetes Study XV: Relationship of renin-angiotensin system gene polymorphisms with microalbuminuria in NIDDM" @default.
- W2004258568 cites W1964232038 @default.
- W2004258568 cites W1986924251 @default.
- W2004258568 cites W2013709047 @default.
- W2004258568 cites W2023362855 @default.
- W2004258568 cites W2026842337 @default.
- W2004258568 cites W2034072566 @default.
- W2004258568 cites W2034331149 @default.
- W2004258568 cites W2043600435 @default.
- W2004258568 cites W2067193509 @default.
- W2004258568 cites W2067970384 @default.
- W2004258568 cites W2073264424 @default.
- W2004258568 cites W2096810815 @default.
- W2004258568 cites W2097532633 @default.
- W2004258568 cites W2154678214 @default.
- W2004258568 cites W2324579467 @default.
- W2004258568 cites W2338236627 @default.
- W2004258568 cites W2944448728 @default.
- W2004258568 cites W4255885452 @default.
- W2004258568 cites W4323238053 @default.
- W2004258568 doi "https://doi.org/10.1038/ki.1995.490" @default.
- W2004258568 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8587251" @default.
- W2004258568 hasPublicationYear "1995" @default.
- W2004258568 type Work @default.
- W2004258568 sameAs 2004258568 @default.
- W2004258568 citedByCount "75" @default.
- W2004258568 countsByYear W20042585682014 @default.
- W2004258568 countsByYear W20042585682022 @default.
- W2004258568 crossrefType "journal-article" @default.
- W2004258568 hasAuthorship W2004258568A5007719363 @default.
- W2004258568 hasAuthorship W2004258568A5013921395 @default.
- W2004258568 hasAuthorship W2004258568A5035095307 @default.
- W2004258568 hasAuthorship W2004258568A5064727417 @default.
- W2004258568 hasAuthorship W2004258568A5086462179 @default.
- W2004258568 hasBestOaLocation W20042585681 @default.
- W2004258568 hasConcept C104317684 @default.
- W2004258568 hasConcept C126322002 @default.
- W2004258568 hasConcept C134018914 @default.
- W2004258568 hasConcept C135763542 @default.
- W2004258568 hasConcept C176674119 @default.
- W2004258568 hasConcept C2776174234 @default.
- W2004258568 hasConcept C2781203188 @default.
- W2004258568 hasConcept C54355233 @default.
- W2004258568 hasConcept C555293320 @default.
- W2004258568 hasConcept C71924100 @default.
- W2004258568 hasConcept C84393581 @default.
- W2004258568 hasConcept C86803240 @default.
- W2004258568 hasConceptScore W2004258568C104317684 @default.
- W2004258568 hasConceptScore W2004258568C126322002 @default.
- W2004258568 hasConceptScore W2004258568C134018914 @default.
- W2004258568 hasConceptScore W2004258568C135763542 @default.
- W2004258568 hasConceptScore W2004258568C176674119 @default.
- W2004258568 hasConceptScore W2004258568C2776174234 @default.
- W2004258568 hasConceptScore W2004258568C2781203188 @default.
- W2004258568 hasConceptScore W2004258568C54355233 @default.
- W2004258568 hasConceptScore W2004258568C555293320 @default.
- W2004258568 hasConceptScore W2004258568C71924100 @default.
- W2004258568 hasConceptScore W2004258568C84393581 @default.
- W2004258568 hasConceptScore W2004258568C86803240 @default.
- W2004258568 hasIssue "6" @default.
- W2004258568 hasLocation W20042585681 @default.
- W2004258568 hasLocation W20042585682 @default.
- W2004258568 hasOpenAccess W2004258568 @default.
- W2004258568 hasPrimaryLocation W20042585681 @default.
- W2004258568 hasRelatedWork W1788227665 @default.
- W2004258568 hasRelatedWork W2096530603 @default.
- W2004258568 hasRelatedWork W2167025527 @default.
- W2004258568 hasRelatedWork W2168520784 @default.
- W2004258568 hasRelatedWork W2281013122 @default.
- W2004258568 hasRelatedWork W2316254627 @default.
- W2004258568 hasRelatedWork W2353026197 @default.
- W2004258568 hasRelatedWork W2392356342 @default.
- W2004258568 hasRelatedWork W2417231003 @default.
- W2004258568 hasRelatedWork W2622233513 @default.
- W2004258568 hasVolume "48" @default.
- W2004258568 isParatext "false" @default.
- W2004258568 isRetracted "false" @default.
- W2004258568 magId "2004258568" @default.
- W2004258568 workType "article" @default.