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- W2004258712 endingPage "E207" @default.
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- W2004258712 abstract "The successful clinical application of polymer-protein conjugates (PE Gylated enzymes and cytokines) and the promising results arising from clinical trials with polymerbound chemotherapy (eg, doxorubicin or paclitaxel) have established their potential to reduce toxicity and improve activity in chemotherapy-refractory patients. Furthermore, and more important, they have also provided a firm foundation for more sophisticated second-generation constructs that deliver the newly energing target-directed bioactive agents (eg, modulators of apoptosis, cell cycle, anti-angiogenic drugs) in addition to polymer-based drug combinations (eg, endocrine therapy and chemotherapy). This review will focus on polymer-drug conjugate modulators of cellular apoptosis to be used as single pro-poptotic (eg, cancer) or anti-apoptotic (eg, ischemia) agents or as a combination therapy." @default.
- W2004258712 created "2016-06-24" @default.
- W2004258712 creator A5083919487 @default.
- W2004258712 date "2007-06-01" @default.
- W2004258712 modified "2023-10-16" @default.
- W2004258712 title "Polymer-drug conjugates as modulators of cellular apoptosis" @default.
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- W2004258712 doi "https://doi.org/10.1208/aapsj0902022" @default.
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