Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004260172> ?p ?o ?g. }
- W2004260172 endingPage "1196" @default.
- W2004260172 startingPage "1196" @default.
- W2004260172 abstract "Oxygen dependent modulation of red blood cell metabolism is a long investigated issue. However, the recent introduction of novel mass spectrometry-based approaches lends itself to implement our understanding of the effects of red blood cell prolonged exposure to anaerobiosis. Indeed, most of the studies conducted so far have addressed the short term issue, while the limited body of literature covering a 42 days storage period only takes into account a handful of metabolic parameters (ATP, DPG, glucose, glyceraldehyde 3-phosphate, and lactate). We hereby performed a mass spectrometry-based untargeted metabolomics analysis in order to highlight metabolic species in erythrocyte concentrates stored anaerobically in SAGM additive solutions for up to 42 days, by testing cells on a weekly basis. We could confirm previous evidence about long term anaerobiosis promoting glycolytic metabolism in RBCs and prolonging the conservation of high energy phosphate reservoirs and purine homeostasis. In parallel, we evidenced that, in contrast to aerobic storage, anaerobiosis impairs erythrocyte capacity to cope with oxidative stress by blocking metabolic diversion towards the pentose phosphate pathway, which negatively affects glutathione homeostasis. Therefore, although oxidative stress was less sustained than in aerobically stored counterparts, oxidative stress markers still accumulate over anaerobic storage progression." @default.
- W2004260172 created "2016-06-24" @default.
- W2004260172 creator A5025588603 @default.
- W2004260172 creator A5045175167 @default.
- W2004260172 creator A5088261186 @default.
- W2004260172 date "2013-01-01" @default.
- W2004260172 modified "2023-10-12" @default.
- W2004260172 title "Red blood cell metabolism under prolonged anaerobic storage" @default.
- W2004260172 cites W110015758 @default.
- W2004260172 cites W1499024850 @default.
- W2004260172 cites W1512735145 @default.
- W2004260172 cites W1588473506 @default.
- W2004260172 cites W1602714920 @default.
- W2004260172 cites W1606508026 @default.
- W2004260172 cites W1780605602 @default.
- W2004260172 cites W1870391416 @default.
- W2004260172 cites W1923295116 @default.
- W2004260172 cites W1965518203 @default.
- W2004260172 cites W1966127509 @default.
- W2004260172 cites W1967694347 @default.
- W2004260172 cites W1977572904 @default.
- W2004260172 cites W1978467824 @default.
- W2004260172 cites W1985811899 @default.
- W2004260172 cites W1988978118 @default.
- W2004260172 cites W1991036755 @default.
- W2004260172 cites W1991518185 @default.
- W2004260172 cites W1993118207 @default.
- W2004260172 cites W1996202330 @default.
- W2004260172 cites W1998093640 @default.
- W2004260172 cites W1998970128 @default.
- W2004260172 cites W2005003386 @default.
- W2004260172 cites W2010156173 @default.
- W2004260172 cites W2012575229 @default.
- W2004260172 cites W2016894199 @default.
- W2004260172 cites W2018954306 @default.
- W2004260172 cites W2023951767 @default.
- W2004260172 cites W2026978187 @default.
- W2004260172 cites W2027021033 @default.
- W2004260172 cites W2029729566 @default.
- W2004260172 cites W2031039124 @default.
- W2004260172 cites W2037045302 @default.
- W2004260172 cites W2043451976 @default.
- W2004260172 cites W2048539872 @default.
- W2004260172 cites W2053385401 @default.
- W2004260172 cites W2054080005 @default.
- W2004260172 cites W2056176539 @default.
- W2004260172 cites W2061990569 @default.
- W2004260172 cites W2062222093 @default.
- W2004260172 cites W2066815783 @default.
- W2004260172 cites W2067520432 @default.
- W2004260172 cites W2067724473 @default.
- W2004260172 cites W2068808038 @default.
- W2004260172 cites W2073502400 @default.
- W2004260172 cites W2081393812 @default.
- W2004260172 cites W2084375915 @default.
- W2004260172 cites W2084628896 @default.
- W2004260172 cites W2085022339 @default.
- W2004260172 cites W2086331440 @default.
- W2004260172 cites W2086534621 @default.
- W2004260172 cites W2087570879 @default.
- W2004260172 cites W2088718155 @default.
- W2004260172 cites W2089026326 @default.
- W2004260172 cites W2089030786 @default.
- W2004260172 cites W2090341125 @default.
- W2004260172 cites W2092785365 @default.
- W2004260172 cites W2095357177 @default.
- W2004260172 cites W2096037879 @default.
- W2004260172 cites W2097654356 @default.
- W2004260172 cites W2102170011 @default.
- W2004260172 cites W2104153098 @default.
- W2004260172 cites W2109364373 @default.
- W2004260172 cites W2115075621 @default.
- W2004260172 cites W2116679882 @default.
- W2004260172 cites W2119378143 @default.
- W2004260172 cites W2124053400 @default.
- W2004260172 cites W2126524529 @default.
- W2004260172 cites W2132966139 @default.
- W2004260172 cites W2133081217 @default.
- W2004260172 cites W2136502698 @default.
- W2004260172 cites W2141467202 @default.
- W2004260172 cites W2142862062 @default.
- W2004260172 cites W2142923621 @default.
- W2004260172 cites W2143594274 @default.
- W2004260172 cites W2156779408 @default.
- W2004260172 cites W2161600832 @default.
- W2004260172 cites W2161896199 @default.
- W2004260172 cites W2164469733 @default.
- W2004260172 cites W2166337262 @default.
- W2004260172 cites W2170997652 @default.
- W2004260172 cites W2409232784 @default.
- W2004260172 cites W2414619685 @default.
- W2004260172 cites W2782406530 @default.
- W2004260172 cites W4251606403 @default.
- W2004260172 cites W4294216483 @default.
- W2004260172 cites W66786127 @default.
- W2004260172 doi "https://doi.org/10.1039/c3mb25575a" @default.
- W2004260172 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23426130" @default.
- W2004260172 hasPublicationYear "2013" @default.