FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004265382> ?p ?o ?g. }

• W2004265382 endingPage "2315" @default.
• W2004265382 startingPage "2311" @default.
• W2004265382 abstract "An optimised method of solution cyclisation gave us access to a series of peptides including SLKIDNLD (2). We investigated the crystallographic complexes of the HIV integrase (HIV-IN) catalytic core domain with 13 of the peptides and identified multiple interactions at the binding site, including hydrogen bonds with residues Thr125 and Gln95, that have not previously been described as being accessible within the binding site. We show that the peptides inhibit the interaction of lens epithelium-derived growth factor (LEDGF) with HIV-IN in a proximity AlphaScreen assay and in an assay for the LEDGF enhancement of HIV-IN strand transfer. The interactions identified represent a potential framework for the development of new HIV-IN inhibitors." @default.
• W2004265382 created "2016-06-24" @default.
• W2004265382 creator A5016007101 @default.
• W2004265382 creator A5017595066 @default.
• W2004265382 creator A5038542549 @default.
• W2004265382 creator A5051783225 @default.
• W2004265382 creator A5061319266 @default.
• W2004265382 creator A5064937568 @default.
• W2004265382 creator A5074718133 @default.
• W2004265382 creator A5080790257 @default.
• W2004265382 creator A5085009324 @default.
• W2004265382 creator A5091121313 @default.
• W2004265382 date "2011-08-17" @default.
• W2004265382 modified "2023-10-06" @default.
• W2004265382 title "Crystal Structures of Novel Allosteric Peptide Inhibitors of HIV Integrase Identify New Interactions at the LEDGF Binding Site" @default.
• W2004265382 cites W1964170347 @default.
• W2004265382 cites W1966515818 @default.
• W2004265382 cites W1966539971 @default.
• W2004265382 cites W1985711767 @default.
• W2004265382 cites W1996707183 @default.
• W2004265382 cites W2008820699 @default.
• W2004265382 cites W2031761503 @default.
• W2004265382 cites W2038028931 @default.
• W2004265382 cites W2060369798 @default.
• W2004265382 cites W2071830825 @default.
• W2004265382 cites W2085489729 @default.
• W2004265382 cites W2087445857 @default.
• W2004265382 cites W2088335428 @default.
• W2004265382 cites W2123317697 @default.
• W2004265382 cites W2130607828 @default.
• W2004265382 cites W2136147658 @default.
• W2004265382 cites W2145356148 @default.
• W2004265382 cites W2146841627 @default.
• W2004265382 cites W4243838284 @default.
• W2004265382 doi "https://doi.org/10.1002/cbic.201100350" @default.
• W2004265382 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21850718" @default.
• W2004265382 hasPublicationYear "2011" @default.
• W2004265382 type Work @default.
• W2004265382 sameAs 2004265382 @default.
• W2004265382 citedByCount "30" @default.
• W2004265382 countsByYear W20042653822012 @default.
• W2004265382 countsByYear W20042653822013 @default.
• W2004265382 countsByYear W20042653822014 @default.
• W2004265382 countsByYear W20042653822015 @default.
• W2004265382 countsByYear W20042653822016 @default.
• W2004265382 countsByYear W20042653822018 @default.
• W2004265382 countsByYear W20042653822019 @default.
• W2004265382 countsByYear W20042653822021 @default.
• W2004265382 countsByYear W20042653822023 @default.
• W2004265382 crossrefType "journal-article" @default.
• W2004265382 hasAuthorship W2004265382A5016007101 @default.
• W2004265382 hasAuthorship W2004265382A5017595066 @default.
• W2004265382 hasAuthorship W2004265382A5038542549 @default.
• W2004265382 hasAuthorship W2004265382A5051783225 @default.
• W2004265382 hasAuthorship W2004265382A5061319266 @default.
• W2004265382 hasAuthorship W2004265382A5064937568 @default.
• W2004265382 hasAuthorship W2004265382A5074718133 @default.
• W2004265382 hasAuthorship W2004265382A5080790257 @default.
• W2004265382 hasAuthorship W2004265382A5085009324 @default.
• W2004265382 hasAuthorship W2004265382A5091121313 @default.
• W2004265382 hasConcept C107824862 @default.
• W2004265382 hasConcept C112887158 @default.
• W2004265382 hasConcept C142462285 @default.
• W2004265382 hasConcept C14430832 @default.
• W2004265382 hasConcept C159047783 @default.
• W2004265382 hasConcept C166342909 @default.
• W2004265382 hasConcept C178790620 @default.
• W2004265382 hasConcept C181199279 @default.
• W2004265382 hasConcept C185592680 @default.
• W2004265382 hasConcept C2777302000 @default.
• W2004265382 hasConcept C2779281246 @default.
• W2004265382 hasConcept C2993143319 @default.
• W2004265382 hasConcept C3013748606 @default.
• W2004265382 hasConcept C32909587 @default.
• W2004265382 hasConcept C41183919 @default.
• W2004265382 hasConcept C552990157 @default.
• W2004265382 hasConcept C55493867 @default.
• W2004265382 hasConcept C71240020 @default.
• W2004265382 hasConcept C86803240 @default.
• W2004265382 hasConceptScore W2004265382C107824862 @default.
• W2004265382 hasConceptScore W2004265382C112887158 @default.
• W2004265382 hasConceptScore W2004265382C142462285 @default.
• W2004265382 hasConceptScore W2004265382C14430832 @default.
• W2004265382 hasConceptScore W2004265382C159047783 @default.
• W2004265382 hasConceptScore W2004265382C166342909 @default.
• W2004265382 hasConceptScore W2004265382C178790620 @default.
• W2004265382 hasConceptScore W2004265382C181199279 @default.
• W2004265382 hasConceptScore W2004265382C185592680 @default.
• W2004265382 hasConceptScore W2004265382C2777302000 @default.
• W2004265382 hasConceptScore W2004265382C2779281246 @default.
• W2004265382 hasConceptScore W2004265382C2993143319 @default.
• W2004265382 hasConceptScore W2004265382C3013748606 @default.
• W2004265382 hasConceptScore W2004265382C32909587 @default.
• W2004265382 hasConceptScore W2004265382C41183919 @default.
• W2004265382 hasConceptScore W2004265382C552990157 @default.
• W2004265382 hasConceptScore W2004265382C55493867 @default.
• W2004265382 hasConceptScore W2004265382C71240020 @default.
• W2004265382 hasConceptScore W2004265382C86803240 @default.

• next