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• W2004277714 abstract "We have investigated the role of the N-methyl-D-aspartate (NMDA) receptor, a subtype of glutamate receptor, in the responses of cells in adult cat visual cortex. After intracortical infusion of the NMDA receptor antagonist DL-2-amino-5-phosphonovalerate (DL-APV) for one day, iontophoretic responses to NMDA, to kainate, and to quisqualate revealed a receptor blockade specific to NMDA receptors and extending several millimeters from the cannula. In this region, neuronal responses to visual stimulation were profoundly suppressed, in a manner strongly correlated with the degree of NMDA receptor blockade. Neither NMDA receptor blockade nor activity suppression was caused by the inactive stereoisomer L-APV. Hence, we conclude that NMDA receptors make a major contribution to normal excitatory transmission in adult visual cortex." @default.
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• W2004277714 date "1989-07-01" @default.
• W2004277714 modified "2023-10-09" @default.
• W2004277714 title "Visual responses in adult cat visual cortex depend on N-methyl-D-aspartate receptors." @default.
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• W2004277714 doi "https://doi.org/10.1073/pnas.86.13.5183" @default.
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