Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004279423> ?p ?o ?g. }
- W2004279423 endingPage "907" @default.
- W2004279423 startingPage "895" @default.
- W2004279423 abstract "We describe that Sox11, a member of the group C of the Sox transcription factor family, is critically required during the morphogenetic processes of early eye development, and that lack of Sox11 results in ocular anterior segment dysgenesis (ASD). Sox11-deficient mice show a persistent lens stalk, a delay in lens formation, and the phenotypes of Peters' anomaly and microphthalmia at birth. In addition, the optic fissure does not close in the anterior halves of the eyes resulting in anterior coloboma. The delay in lens formation is associated with a reduced mitotic activity in the lens placode during its invagination into the optic cup. No changes in Pax6 expression are observed in the developing eyes of Sox11−/− mice, whereas the expression of Sox11 is reduced in optic cup, optic vesicle and lens placode of Pax6+/− embryos and in the optic vesicle of Pax6−/− mice. Transfection experiments show an increase in Sox11 expression when higher doses of Pax6 are present. Considerably smaller amounts of BMP7 are expressed in lens and optic cup of Sox11−/− mice as compared to their wild-type littermates. We conclude that Sox11 is required during separation of the lens vesicle from the surface ectoderm and the closure of the anterior optic fissure. The expression of Sox11 in early eye development is under control of Pax6, and changes in BMP7-signalling appear to be involved in the effects of Sox11 on anterior eye development. Our findings suggest that SOX11 might similarly be involved in the pathogenesis of ASD in human patients." @default.
- W2004279423 created "2016-06-24" @default.
- W2004279423 creator A5048511108 @default.
- W2004279423 creator A5051677530 @default.
- W2004279423 creator A5057588758 @default.
- W2004279423 creator A5061665380 @default.
- W2004279423 creator A5067065466 @default.
- W2004279423 date "2008-06-01" @default.
- W2004279423 modified "2023-10-02" @default.
- W2004279423 title "Anterior segment dysgenesis in the eyes of mice deficient for the high-mobility-group transcription factor Sox11" @default.
- W2004279423 cites W1840467085 @default.
- W2004279423 cites W1964525081 @default.
- W2004279423 cites W1964761197 @default.
- W2004279423 cites W1970769812 @default.
- W2004279423 cites W1985251038 @default.
- W2004279423 cites W1985701920 @default.
- W2004279423 cites W1993354416 @default.
- W2004279423 cites W1993399270 @default.
- W2004279423 cites W2002652075 @default.
- W2004279423 cites W2004836501 @default.
- W2004279423 cites W2009664649 @default.
- W2004279423 cites W2012690390 @default.
- W2004279423 cites W2013372950 @default.
- W2004279423 cites W2018598340 @default.
- W2004279423 cites W2021460051 @default.
- W2004279423 cites W2023395045 @default.
- W2004279423 cites W2023497062 @default.
- W2004279423 cites W2024215958 @default.
- W2004279423 cites W2029559054 @default.
- W2004279423 cites W2033690523 @default.
- W2004279423 cites W2034607546 @default.
- W2004279423 cites W2037608579 @default.
- W2004279423 cites W2043218606 @default.
- W2004279423 cites W2043765395 @default.
- W2004279423 cites W2046624631 @default.
- W2004279423 cites W2046711538 @default.
- W2004279423 cites W2047244839 @default.
- W2004279423 cites W2048255666 @default.
- W2004279423 cites W2053655929 @default.
- W2004279423 cites W2060811783 @default.
- W2004279423 cites W2073717167 @default.
- W2004279423 cites W2075598942 @default.
- W2004279423 cites W2082653424 @default.
- W2004279423 cites W2086742420 @default.
- W2004279423 cites W2089407911 @default.
- W2004279423 cites W2090268833 @default.
- W2004279423 cites W2090753900 @default.
- W2004279423 cites W2092060417 @default.
- W2004279423 cites W2102589238 @default.
- W2004279423 cites W2103619902 @default.
- W2004279423 cites W2104957959 @default.
- W2004279423 cites W2106376936 @default.
- W2004279423 cites W2106782757 @default.
- W2004279423 cites W2109177118 @default.
- W2004279423 cites W2110606946 @default.
- W2004279423 cites W2112718652 @default.
- W2004279423 cites W2113423004 @default.
- W2004279423 cites W2114245705 @default.
- W2004279423 cites W2116778410 @default.
- W2004279423 cites W2121934176 @default.
- W2004279423 cites W2124415162 @default.
- W2004279423 cites W2126746915 @default.
- W2004279423 cites W2129282939 @default.
- W2004279423 cites W2132049966 @default.
- W2004279423 cites W2134072592 @default.
- W2004279423 cites W2140572701 @default.
- W2004279423 cites W2143518913 @default.
- W2004279423 cites W2152641758 @default.
- W2004279423 cites W2154100816 @default.
- W2004279423 cites W2161889215 @default.
- W2004279423 cites W2163129996 @default.
- W2004279423 cites W2171508208 @default.
- W2004279423 cites W2171696866 @default.
- W2004279423 cites W2184436455 @default.
- W2004279423 cites W2275611683 @default.
- W2004279423 cites W2403471699 @default.
- W2004279423 cites W343789202 @default.
- W2004279423 cites W4323238746 @default.
- W2004279423 doi "https://doi.org/10.1016/j.exer.2008.03.004" @default.
- W2004279423 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18423449" @default.
- W2004279423 hasPublicationYear "2008" @default.
- W2004279423 type Work @default.
- W2004279423 sameAs 2004279423 @default.
- W2004279423 citedByCount "53" @default.
- W2004279423 countsByYear W20042794232012 @default.
- W2004279423 countsByYear W20042794232013 @default.
- W2004279423 countsByYear W20042794232014 @default.
- W2004279423 countsByYear W20042794232015 @default.
- W2004279423 countsByYear W20042794232016 @default.
- W2004279423 countsByYear W20042794232017 @default.
- W2004279423 countsByYear W20042794232018 @default.
- W2004279423 countsByYear W20042794232019 @default.
- W2004279423 countsByYear W20042794232020 @default.
- W2004279423 countsByYear W20042794232021 @default.
- W2004279423 countsByYear W20042794232022 @default.
- W2004279423 countsByYear W20042794232023 @default.
- W2004279423 crossrefType "journal-article" @default.
- W2004279423 hasAuthorship W2004279423A5048511108 @default.