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- W2004284683 abstract "Abstract 1. 1. Fatty acid synthesis from [1,3-14C2]malonyl-CoA has been studied in ratliver microsomes. In the absence of ATP a substancial fatty acid synthesis was observed. The ratio of total radioactivity to radioactivity in carboxyl carbon of the fatty acids synthesized in these conditions was between 7.6:1 and 7.8:1. 2. 2. In the presence of ATP [1,3-14C2]malonyl-CoA incorporation was increased. Maximal stimulation was observed at 1 mM ATP. In these conditions the ratio of total radioactivity to radioactivity in carboxyl carbon of the fatty acids synthesized was lowered from 7.9:1 to 3.5:1. By increasing the ATP concentration this ratio was further decreased. 3. 3. The results indicated that in rat-liver microsomes two mechanisms of fatty acid synthesis are present: (a) chain elongation and (b) synthesis de novo. Synthesis de novo is operative maximally in the absence of ATP, whereas chain elongation starts to function in the presence of ATP and becomes the major synthetic pathway when the ATP concentration is increased. 4. 4. Palmityl-CoA inhibited fatty acid synthesis de novo; simultaneously chain elongation was promoted. 5. 5. Arsenite and AT-ethylmaleimide inhibited both synthesis de novo and chain elongation. The inhibitory concentrations of these compounds were different for the two mechanisms. Chain elongation was completely inhibited at a concentration of arsenite or N-ethylmaleimide 8–10 times higher than that which completely inhibited synthesis de novo. 6. 6. In the absence of ATP, palmitate was the predominant fatty acid synthesized by rat-liver microsomes, whereas in the presence of ATP, stearate, oleate and longer chain fatty acids were synthesized." @default.
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- W2004284683 title "Mechanisms of fatty acid synthesis in rat-liver microsomes" @default.
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- W2004284683 doi "https://doi.org/10.1016/0005-2760(70)90111-6" @default.
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