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• W2004286879 abstract "beta cell failure is a common denominator of diabetes. Susceptibility to stress-induced apoptosis may underlie beta cell failure and/or hamper islet transplantation therapy. The causal basis is not well understood. In efforts to identify important differences in gene expression in alpha vs. beta cells, a gene termed HIMP1 (Hypoglycemia/hypoxia Inducible Mitochondrial Protein, or HIG1) has been cloned from an alpha cell cDNA library. It is a member of a well conserved eukaryote protein family. In mice, its two alternatively spliced products each form a transmembrane loop, having an N(outside)-C(outside) orientation and are expressed highly in the mitochondrial inner membrane in several tissues including heart and pancreatic alpha cells, but not in beta cells. Ectopic expression of HIMP1 in MIN6 beta cells protects the cells from apoptosis induced by several stimuli and prolongs their survival. These results suggest an important role for HIMP1 in stress protective programs in mitochondria." @default.
• W2004286879 created "2016-06-24" @default.
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• W2004286879 date "2006-07-11" @default.
• W2004286879 modified "2023-09-29" @default.
• W2004286879 title "Pancreatic β cells lack a low glucose and O ₂ -inducible mitochondrial protein that augments cell survival" @default.
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• W2004286879 doi "https://doi.org/10.1073/pnas.0604194103" @default.
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