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- W2004299368 abstract "Previous studies demonstrated that the adjuvant-free form of a fusion protein consisting of a truncated herpes simplex virus type 1 (HSV-1) glycoprotein D and human interleukin-2 (tgD-IL- 2) elicited superior protective immunity in mice. In this study, the immunotherapeutic efficacy of tgD-IL-2 against vaginal HSV-2 infection was investigated using a guinea pig model. Footpad injections of tgD-IL-2 (12.5 µgjdose) after the onset of primary lesions strongly suppressed recurrence in the chronic phase of infection; consequently, the number of days with lesions was reduced 65%. Continuous medication with 100 mg/kgjday acyclovir for 5 days failed to suppress recurrent infection. In a UV radiation-induced recurrence model, prophylactic tgD-IL- 2 significantly suppressed both duration and severity of disease. A single injection of tgD-IL2 plus acyclovir produced an additive effect on the suppression of the disease in the acute phase. These results suggest that tgD-IL-2 is a promising immunotherapeutic agent against HSV-2 genital infections." @default.
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- W2004299368 date "1994-04-01" @default.
- W2004299368 modified "2023-10-18" @default.
- W2004299368 title "Immunotherapy of Acute and Recurrent Herpes Simplex Virus Type 2 Infection with an Adjuvant-Free Form of Recombinant Glycoprotein D-Interleukin-2 Fusion Protein" @default.
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- W2004299368 doi "https://doi.org/10.1093/infdis/169.4.787" @default.
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