Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004321654> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W2004321654 endingPage "S411" @default.
- W2004321654 startingPage "S410" @default.
- W2004321654 abstract "The aim of this study was to examine the relationships between glycogen synthase 3β gene polymorphisms and bipolar I disorder, manic in a Korean sample.Patients with bipolar disorder (n = 118) and a control group (n = 158) were assessed by genotyping for GSK3β single nucleotide polymorphisms (SNPs) − 1727A/T and − 50C/T. The patients were divided into two groups according to the presence of psychotic symptoms (psychotic mania, n = 92; non-psychotic mania, n = 26) and also divided based on gender and age of onset. The severity of symptoms was measured using the Young Mania Rating Scale (YMRS) and the Brief Psychiatric Rating Scale (BPRS).There were no significant differences in the genotype distributions or allelic frequencies of GSK3β polymorphisms and gender between patients with bipolar disorder and a normal control group. According to haplotype analysis, there was no association between these two groups. However, analysis of the age of onset of bipolar disorder revealed significant differences in genotype and allele distributions among the patients. Patients who were homozygous for the wild-type variant (TT) had an older age of onset than carriers of the mutant allele (A/A: 27.4 ± 9.1; A/T: 30.1 ± 11.8; T/T: 42.3 ± 19.9; p = 0.034). We detected differences in allele frequencies of the GSK3β − 1727A/T polymorphism between the psychotic mania group and the non-psychotic mania group.This study suggests that GSK3β polymorphisms are not associated with bipolar disorder. However, the GSK3β SNP − 1727A/T is associated with age of onset and presence of psychotic symptoms in bipolar disorder." @default.
- W2004321654 created "2016-06-24" @default.
- W2004321654 creator A5013270045 @default.
- W2004321654 date "2010-08-01" @default.
- W2004321654 modified "2023-10-18" @default.
- W2004321654 title "P.2.e.015 Clinical trials to clinical practice: retrospective analysis of 25 patients with bipolar mania treated with aripiprazole" @default.
- W2004321654 doi "https://doi.org/10.1016/s0924-977x(10)70588-5" @default.
- W2004321654 hasPublicationYear "2010" @default.
- W2004321654 type Work @default.
- W2004321654 sameAs 2004321654 @default.
- W2004321654 citedByCount "0" @default.
- W2004321654 crossrefType "journal-article" @default.
- W2004321654 hasAuthorship W2004321654A5013270045 @default.
- W2004321654 hasConcept C104317684 @default.
- W2004321654 hasConcept C118552586 @default.
- W2004321654 hasConcept C126322002 @default.
- W2004321654 hasConcept C135763542 @default.
- W2004321654 hasConcept C153209595 @default.
- W2004321654 hasConcept C15744967 @default.
- W2004321654 hasConcept C180754005 @default.
- W2004321654 hasConcept C2776174506 @default.
- W2004321654 hasConcept C2776809841 @default.
- W2004321654 hasConcept C2777089681 @default.
- W2004321654 hasConcept C2778528637 @default.
- W2004321654 hasConcept C2778541603 @default.
- W2004321654 hasConcept C2778609679 @default.
- W2004321654 hasConcept C2779727114 @default.
- W2004321654 hasConcept C54355233 @default.
- W2004321654 hasConcept C71924100 @default.
- W2004321654 hasConcept C86803240 @default.
- W2004321654 hasConcept C90924648 @default.
- W2004321654 hasConceptScore W2004321654C104317684 @default.
- W2004321654 hasConceptScore W2004321654C118552586 @default.
- W2004321654 hasConceptScore W2004321654C126322002 @default.
- W2004321654 hasConceptScore W2004321654C135763542 @default.
- W2004321654 hasConceptScore W2004321654C153209595 @default.
- W2004321654 hasConceptScore W2004321654C15744967 @default.
- W2004321654 hasConceptScore W2004321654C180754005 @default.
- W2004321654 hasConceptScore W2004321654C2776174506 @default.
- W2004321654 hasConceptScore W2004321654C2776809841 @default.
- W2004321654 hasConceptScore W2004321654C2777089681 @default.
- W2004321654 hasConceptScore W2004321654C2778528637 @default.
- W2004321654 hasConceptScore W2004321654C2778541603 @default.
- W2004321654 hasConceptScore W2004321654C2778609679 @default.
- W2004321654 hasConceptScore W2004321654C2779727114 @default.
- W2004321654 hasConceptScore W2004321654C54355233 @default.
- W2004321654 hasConceptScore W2004321654C71924100 @default.
- W2004321654 hasConceptScore W2004321654C86803240 @default.
- W2004321654 hasConceptScore W2004321654C90924648 @default.
- W2004321654 hasLocation W20043216541 @default.
- W2004321654 hasOpenAccess W2004321654 @default.
- W2004321654 hasPrimaryLocation W20043216541 @default.
- W2004321654 hasRelatedWork W1989933634 @default.
- W2004321654 hasRelatedWork W2004321654 @default.
- W2004321654 hasRelatedWork W2027763454 @default.
- W2004321654 hasRelatedWork W2059896379 @default.
- W2004321654 hasRelatedWork W2101379983 @default.
- W2004321654 hasRelatedWork W2139099551 @default.
- W2004321654 hasRelatedWork W2726743474 @default.
- W2004321654 hasRelatedWork W3095716871 @default.
- W2004321654 hasRelatedWork W3117801596 @default.
- W2004321654 hasRelatedWork W3141197980 @default.
- W2004321654 hasVolume "20" @default.
- W2004321654 isParatext "false" @default.
- W2004321654 isRetracted "false" @default.
- W2004321654 magId "2004321654" @default.
- W2004321654 workType "article" @default.