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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004321809> ?p ?o ?g. }

• W2004321809 endingPage "196" @default.
• W2004321809 startingPage "189" @default.
• W2004321809 abstract "Under experimental conditions optimal for the assay of D-galactosyl-N-acylsphingosine galactohydrolase (EC 3.2.1.46) activity, homogenates of neurologically normal human brain tissue could transfer galactose from galactosyl ceramide (gal-cer), lactosyl ceramide (lac-cer), 4-methylumbelliferyl-beta-galactoside (4-MU-gal), or p-nitrophenyl-beta-galactoside (PNP-gal) to [1-14C]oleoyl sphingosine, but homogenates of brain tissue from patients with Krabbe's disease lacked this ability. The rate of hydrolysis of ganglioside GM1 and, to a lesser extent, of PNP-gal by homogenates of Krabbe's brain tissue was also decreased. Activity of PNP-beta-galactosidase in normal brain tissue, like that of cerebroside beta-galactosidase from the same source, was considerably more heat-stable than the activity of either 4-MU-beta-galactosidase or the predominant GM1 beta-D-galactosidase (EC 3.2.1.23). Lac-cer and GM1, as well as 4-MU-gal and PNP-gal, were competitive inhibitors of human-brain cerebroside beta-galactosidase. These findings confirm the ability of mammalian cerebroside beta-galactosidase to catalyze a transgalactosylation reaction and provide additional information on the substrate specificity of human brain cerebroside beta-galactosidase." @default.
• W2004321809 created "2016-06-24" @default.
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• W2004321809 date "1980-01-01" @default.
• W2004321809 modified "2023-09-27" @default.
• W2004321809 title "Human Brain Cerebroside ?-Galactosidase: Deficiency of Transgalactosidic Activity in Krabbe's Disease" @default.
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• W2004321809 doi "https://doi.org/10.1111/j.1471-4159.1980.tb04639.x" @default.
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