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- W2004322578 abstract "Treatment of idiopathic thrombocytopenic purpura (ITP) with high-dose intravenous immunoglobulins has been shown to be effective in several studies. It has not been demonstrated which part of the immunoglobulin molecule is decisive for the therapeutic effect. Based on a pilot study comparing 3.5 S, 5 S and 7 S-immunoglobulin (Ig) G which yielded treatment responses in each group, a prospective randomized study was conducted. This investigation compared a 7 S-IgG regimen to a 5 S-IgG regimen. The 7 S-IgG was prepared by limited sulfitolysis. The 5 S-F(ab)2-preparation was produced by pepsin cleavage. Thrombocytopenic patients (platelet counts <30×109/1) were assigned to the treatment regimens randomly. Both groups were given 400 mg/kg body-weight Ig over 5 days. 9/10 patients in the 7 S treatment group responded to therapy compared to 3/10 patients in the 5 S treatment group (p = 0.0099 by Fisher's exact test). The mean platelet count 4 days after the last infusion was 209.5±136.7 × 109/1 (x±S.E.M.) in the 7 S group compared to 79.7±75.0 × 109/1 in the 5 S group. The results of the study emphasize the necessity of the IgG molecule's pFc-part, which is contained in the 7 S preparation." @default.
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- W2004322578 date "1985-04-01" @default.
- W2004322578 modified "2023-09-25" @default.
- W2004322578 title "890 MECHANISM OF INTRAVENOUS IMMUNOGLOBULIN TREATMENT IN CHILDHOOD ACUTE IDIOPATHIC THROMBOCYTOPENIC PURPURA. COMPARISON OF F(ab)2 VERSUS pFc CONTAINING IgG" @default.
- W2004322578 doi "https://doi.org/10.1203/00006450-198504000-00920" @default.
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