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• W2004331136 endingPage "111" @default.
• W2004331136 startingPage "99" @default.
• W2004331136 abstract "The E2 open reading frame of bovine papillomavirus (BPV)-1 encodes a 410 amino acid (aa) transcriptional activator, E2-TA, and collinear polypeptides--E2-TR (243 aa) and E8^E2 (196 aa). E8^E2 and E2-TR share the DNA-binding domain of E2-TA, and both have been defined as transcriptional repressors. Although purified E2-TR and E8^E2 proteins specifically bound E2 sites with similar affinities, only the E2-TR stimulated transcription. Here we show that E2-TR trans-activates E2-dependent promoters 5 to 10-fold in cooperation with cellular factors and in a dose-dependent fashion in epithelial cells and fibroblasts of animal or human origin while E2-TA activated >100-fold and the E8^E2 had no effect. However, in contrast to E2-TA, E2-TR activated transcription from a promoter-proximal position. E2-TR also partially inhibited the BPV-1 P89 or heterologous promoters whereas E8^E2 led to complete repression. Thus, the BPV-1 E2-TR modulates viral gene expression in a manner distinct from other E2 proteins." @default.
• W2004331136 created "2016-06-24" @default.
• W2004331136 creator A5001411224 @default.
• W2004331136 creator A5044013855 @default.
• W2004331136 creator A5056487501 @default.
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• W2004331136 creator A5087161908 @default.
• W2004331136 creator A5088684978 @default.
• W2004331136 creator A5090977212 @default.
• W2004331136 date "2012-08-01" @default.
• W2004331136 modified "2023-09-29" @default.
• W2004331136 title "The truncated C-terminal E2 (E2-TR) protein of bovine papillomavirus (BPV) type-1 is a transactivator that modulates transcription in vivo and in vitro in a manner distinct from the E2-TA and E8^E2 gene products" @default.
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• W2004331136 doi "https://doi.org/10.1016/j.virol.2012.03.020" @default.
• W2004331136 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22551766" @default.
• W2004331136 hasPublicationYear "2012" @default.
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• W2004331136 hasAuthorship W2004331136A5056487501 @default.

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