Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004332355> ?p ?o ?g. }
- W2004332355 endingPage "176" @default.
- W2004332355 startingPage "168" @default.
- W2004332355 abstract "Iron is a micronutrient essential for almost all organisms: bacteria, plants, and animals. It is a metal that exists in multiple redox states, including the divalent ferrous (Fe(2+)) and the trivalent ferric (Fe(3+)) species. The multiple oxidation states of iron make it excellent for electron transfer, allowing iron to be selected during evolution as a cofactor for many proteins involved in central cellular processes including oxygen transport, mitochondrial respiration, and DNA synthesis. However, the redox cycling of ferrous and ferric iron in the presence of H2O2, which is physiologically present in the cells, also leads to the production of free radicals (Fenton reaction) that can attack and damage lipids, proteins, DNA, and other cellular components. To meet the physiological needs of the body, but to prevent cellular damage by iron, the amount of iron in the body must be tightly regulated. Here we review how the liver is the central conductor of systemic iron balance and show that this central role is related to the secretion of a peptide hormone hepcidin by hepatocytes. We then review how the liver receives and integrates the many signals that report the body's iron needs to orchestrate hepcidin production and maintain systemic iron homeostasis." @default.
- W2004332355 created "2016-06-24" @default.
- W2004332355 creator A5002713704 @default.
- W2004332355 creator A5036703144 @default.
- W2004332355 creator A5054211573 @default.
- W2004332355 date "2014-01-09" @default.
- W2004332355 modified "2023-10-12" @default.
- W2004332355 title "The liver: conductor of systemic iron balance" @default.
- W2004332355 cites W1618001767 @default.
- W2004332355 cites W1963860082 @default.
- W2004332355 cites W1965288056 @default.
- W2004332355 cites W1967145414 @default.
- W2004332355 cites W1967479447 @default.
- W2004332355 cites W1969159818 @default.
- W2004332355 cites W1970714562 @default.
- W2004332355 cites W1973313690 @default.
- W2004332355 cites W1974266372 @default.
- W2004332355 cites W1976484400 @default.
- W2004332355 cites W1977767277 @default.
- W2004332355 cites W1979307757 @default.
- W2004332355 cites W1979388939 @default.
- W2004332355 cites W1980042430 @default.
- W2004332355 cites W1980663890 @default.
- W2004332355 cites W1980769878 @default.
- W2004332355 cites W1983077005 @default.
- W2004332355 cites W1983970155 @default.
- W2004332355 cites W1984773555 @default.
- W2004332355 cites W1985099261 @default.
- W2004332355 cites W1990597287 @default.
- W2004332355 cites W1992203007 @default.
- W2004332355 cites W1995768948 @default.
- W2004332355 cites W2002605005 @default.
- W2004332355 cites W2004724037 @default.
- W2004332355 cites W2005389846 @default.
- W2004332355 cites W2005438156 @default.
- W2004332355 cites W2009988274 @default.
- W2004332355 cites W2012068458 @default.
- W2004332355 cites W2012598190 @default.
- W2004332355 cites W2012956876 @default.
- W2004332355 cites W2021552825 @default.
- W2004332355 cites W2023209642 @default.
- W2004332355 cites W2024047211 @default.
- W2004332355 cites W2025063713 @default.
- W2004332355 cites W2025158365 @default.
- W2004332355 cites W2027090078 @default.
- W2004332355 cites W2027924212 @default.
- W2004332355 cites W2028113369 @default.
- W2004332355 cites W2029899420 @default.
- W2004332355 cites W2033465391 @default.
- W2004332355 cites W2038731528 @default.
- W2004332355 cites W2041489148 @default.
- W2004332355 cites W2043118364 @default.
- W2004332355 cites W2043254960 @default.
- W2004332355 cites W2043349967 @default.
- W2004332355 cites W2047642636 @default.
- W2004332355 cites W2048448975 @default.
- W2004332355 cites W2049912996 @default.
- W2004332355 cites W2049917711 @default.
- W2004332355 cites W2050656944 @default.
- W2004332355 cites W2050833520 @default.
- W2004332355 cites W2052311092 @default.
- W2004332355 cites W2054149566 @default.
- W2004332355 cites W2054421541 @default.
- W2004332355 cites W2054812644 @default.
- W2004332355 cites W2056282179 @default.
- W2004332355 cites W2058062704 @default.
- W2004332355 cites W2059778114 @default.
- W2004332355 cites W2061390170 @default.
- W2004332355 cites W2062163666 @default.
- W2004332355 cites W2063162117 @default.
- W2004332355 cites W2066497688 @default.
- W2004332355 cites W2066937360 @default.
- W2004332355 cites W2067125890 @default.
- W2004332355 cites W2067747556 @default.
- W2004332355 cites W2068382047 @default.
- W2004332355 cites W2068396332 @default.
- W2004332355 cites W2069594569 @default.
- W2004332355 cites W2070165530 @default.
- W2004332355 cites W2076911359 @default.
- W2004332355 cites W2077581849 @default.
- W2004332355 cites W2078956328 @default.
- W2004332355 cites W2080200109 @default.
- W2004332355 cites W2083240311 @default.
- W2004332355 cites W2083359289 @default.
- W2004332355 cites W2085755944 @default.
- W2004332355 cites W2088475546 @default.
- W2004332355 cites W2090165219 @default.
- W2004332355 cites W2092229445 @default.
- W2004332355 cites W2094748234 @default.
- W2004332355 cites W2095400049 @default.
- W2004332355 cites W2095421717 @default.
- W2004332355 cites W2104896102 @default.
- W2004332355 cites W2107032226 @default.
- W2004332355 cites W2107423980 @default.
- W2004332355 cites W2107704801 @default.
- W2004332355 cites W2108843246 @default.
- W2004332355 cites W2113191401 @default.
- W2004332355 cites W2113642938 @default.