FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004333640> ?p ?o ?g. }

• W2004333640 abstract "Although the identification of menin-interacting partners and other evidence support a role for menin, the multiple endocrine neoplasia type 1 gene (MEN1) product, in regulating gene expression, little is known about the cellular pathways dysregulated by menin loss during tumorigenesis. The mouse models of MEN1 accurately mimic the human syndrome and provide an opportunity to assess the transcriptional effects of Men1 deletion in different endocrine tumor types to identify common pathway aberrations underlying tumorigenesis in MEN1-affected tissues. We compared the global gene expression profiles of pituitary adenomas and pancreatic islet tumors with control tissues from wild-type littermates. Amongst the 551 differentially expressed genes was significant over-representation of genes associated with chromatin remodelling, transcription and cell cycling, including some genes known to encode menin-binding partners, e.g., Rhox5 and Mll1. Consistent with increased cell-cycle transition from G1 to S phase was an elevation of Cdc7 expression in the tumors, which was confirmed by qRT-PCR using independent samples. In support of previous findings in islet tumors, we found down-regulation of the cell-cycle regulator, p18, in both the pancreatic islet and pituitary adenomas, suggesting that reduced p18 levels may be important for Men1-related tumorigenesis in multiple tissues. Surprisingly, we identified increased p16 transcript in pancreatic islet and pituitary tumors. This was accompanied by increased cytoplasmic localization p16 protein in tumor cells. The specific genes and general pathways we have found to be commonly dysregulated in MEN1 tumors, provide a platform for determining their roles in endocrine tumorigenesis." @default.
• W2004333640 created "2016-06-24" @default.
• W2004333640 creator A5022592999 @default.
• W2004333640 creator A5023433226 @default.
• W2004333640 creator A5034115189 @default.
• W2004333640 creator A5047949525 @default.
• W2004333640 creator A5058728224 @default.
• W2004333640 creator A5062225042 @default.
• W2004333640 creator A5077904082 @default.
• W2004333640 creator A5079448845 @default.
• W2004333640 date "2007-08-15" @default.
• W2004333640 modified "2023-09-23" @default.
• W2004333640 title "Global expression profiling of murine MEN1-associated tumors reveals a regulatory role for menin in transcription, cell cycle and chromatin remodelling" @default.
• W2004333640 cites W1549694960 @default.
• W2004333640 cites W1577219436 @default.
• W2004333640 cites W1593105928 @default.
• W2004333640 cites W1704269168 @default.
• W2004333640 cites W1970749764 @default.
• W2004333640 cites W1975603512 @default.
• W2004333640 cites W1976990715 @default.
• W2004333640 cites W1978831895 @default.
• W2004333640 cites W1988517195 @default.
• W2004333640 cites W1993143177 @default.
• W2004333640 cites W2011684685 @default.
• W2004333640 cites W2014386433 @default.
• W2004333640 cites W2014409530 @default.
• W2004333640 cites W2015188570 @default.
• W2004333640 cites W2020483638 @default.
• W2004333640 cites W2023367466 @default.
• W2004333640 cites W2036681136 @default.
• W2004333640 cites W2041896049 @default.
• W2004333640 cites W2048295632 @default.
• W2004333640 cites W2057081754 @default.
• W2004333640 cites W2063137811 @default.
• W2004333640 cites W2063882402 @default.
• W2004333640 cites W2066515353 @default.
• W2004333640 cites W2070539933 @default.
• W2004333640 cites W2071178044 @default.
• W2004333640 cites W2071742040 @default.
• W2004333640 cites W2074883939 @default.
• W2004333640 cites W2076984763 @default.
• W2004333640 cites W2077536614 @default.
• W2004333640 cites W2082941836 @default.
• W2004333640 cites W2084239507 @default.
• W2004333640 cites W2084618069 @default.
• W2004333640 cites W2096976625 @default.
• W2004333640 cites W2100171549 @default.
• W2004333640 cites W2111301538 @default.
• W2004333640 cites W2114671894 @default.
• W2004333640 cites W2116229314 @default.
• W2004333640 cites W2116702160 @default.
• W2004333640 cites W2124584525 @default.
• W2004333640 cites W2127976626 @default.
• W2004333640 cites W2142747205 @default.
• W2004333640 cites W2149015774 @default.
• W2004333640 cites W2150056778 @default.
• W2004333640 cites W2150111853 @default.
• W2004333640 cites W2150212366 @default.
• W2004333640 cites W2152534875 @default.
• W2004333640 cites W2154218976 @default.
• W2004333640 cites W2155456705 @default.
• W2004333640 cites W2157212789 @default.
• W2004333640 cites W2162942974 @default.
• W2004333640 cites W2164513602 @default.
• W2004333640 cites W2170356169 @default.
• W2004333640 cites W2335026293 @default.
• W2004333640 doi "https://doi.org/10.1002/ijc.22734" @default.
• W2004333640 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17455252" @default.
• W2004333640 hasPublicationYear "2007" @default.
• W2004333640 type Work @default.
• W2004333640 sameAs 2004333640 @default.
• W2004333640 citedByCount "21" @default.
• W2004333640 countsByYear W20043336402012 @default.
• W2004333640 countsByYear W20043336402013 @default.
• W2004333640 countsByYear W20043336402014 @default.
• W2004333640 countsByYear W20043336402016 @default.
• W2004333640 countsByYear W20043336402017 @default.
• W2004333640 countsByYear W20043336402019 @default.
• W2004333640 crossrefType "journal-article" @default.
• W2004333640 hasAuthorship W2004333640A5022592999 @default.
• W2004333640 hasAuthorship W2004333640A5023433226 @default.
• W2004333640 hasAuthorship W2004333640A5034115189 @default.
• W2004333640 hasAuthorship W2004333640A5047949525 @default.
• W2004333640 hasAuthorship W2004333640A5058728224 @default.
• W2004333640 hasAuthorship W2004333640A5062225042 @default.
• W2004333640 hasAuthorship W2004333640A5077904082 @default.
• W2004333640 hasAuthorship W2004333640A5079448845 @default.
• W2004333640 hasBestOaLocation W20043336401 @default.
• W2004333640 hasConcept C104317684 @default.
• W2004333640 hasConcept C165864922 @default.
• W2004333640 hasConcept C2779469564 @default.
• W2004333640 hasConcept C2780103800 @default.
• W2004333640 hasConcept C29537977 @default.
• W2004333640 hasConcept C502942594 @default.
• W2004333640 hasConcept C54355233 @default.
• W2004333640 hasConcept C555283112 @default.
• W2004333640 hasConcept C83640560 @default.
• W2004333640 hasConcept C86339819 @default.
• W2004333640 hasConcept C86803240 @default.
• W2004333640 hasConcept C95444343 @default.

• next