FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004334615> ?p ?o ?g. }

• W2004334615 endingPage "170" @default.
• W2004334615 startingPage "166" @default.
• W2004334615 abstract "The authors investigated the effectiveness of idebenone combined with vitamin B2 and vitamin C in the treatment of patients with Leber hereditary optic neuropathy (LHON) in an early stage as compared with untreated patients with LHON. These agents may stimulate the formation of ATP.For this retrospective study, the authors selected 28 outpatients with LHON from the Keio University Hospital. These patients were followed for 2 to 19 years from disease onset. They were divided into two groups: 14 untreated patients (11778 mutation in 10 patients, 3460 mutation in 2 patients, and 14484 mutation in 2 two patients); and 14 treated patients (11778 mutation in 11 patients, 3460 mutation in 1 patient, and 14484 mutation in 2 patients). The treated patients were administered medical treatment with idebenone, vitamin B2, and vitamin C for at least 1 year. The current study evaluated the following: 1) number of eyes with visual recovery > or = 0.3; 2) interval between the onset of LHON and the beginning of visual recovery; 3) interval between the onset of LHON and visual recovery to 0.3; and 4) interval between the beginning of medical treatment and the beginning of visual recovery in the treated subjects.There was no significant difference in the number of eyes with visual recovery > or = 0.3 in the two groups with the 3460, 11778, or 14484 mutation. Patients with visual recovery showed a fenestrated scotoma or a clearing of central vision. The mean interval between the onset of LHON and the beginning of visual recovery was significantly shorter in the treated group (11.1 months) than in the untreated group (17.4 months) (P = 0.03). The mean interval between the onset of LHON and visual recovery to 0.3 was significantly shorter in the treated group (17.6 months) than in the untreated group (34.4 months) (P = 0.01). The mean interval between the initiation of medical treatment to the beginning of visual recovery was 5.4 months.Results suggest that the administration of idebenone, vitamin B2, and vitamin C sped the recovery of vision in patients with LHON." @default.
• W2004334615 created "2016-06-24" @default.
• W2004334615 creator A5003537669 @default.
• W2004334615 creator A5013537921 @default.
• W2004334615 creator A5049222256 @default.
• W2004334615 creator A5055727790 @default.
• W2004334615 date "2000-09-01" @default.
• W2004334615 modified "2023-10-06" @default.
• W2004334615 title "Do Idebenone and Vitamin Therapy Shorten the Time to Achieve Visual Recovery in Leber Hereditary Optic Neuropathy?" @default.
• W2004334615 cites W156469326 @default.
• W2004334615 cites W1569178623 @default.
• W2004334615 cites W1974779272 @default.
• W2004334615 cites W1993215625 @default.
• W2004334615 cites W1996282241 @default.
• W2004334615 cites W2007830544 @default.
• W2004334615 cites W2010298389 @default.
• W2004334615 cites W2013903677 @default.
• W2004334615 cites W2028040726 @default.
• W2004334615 cites W2028661345 @default.
• W2004334615 cites W2051245777 @default.
• W2004334615 cites W2052109297 @default.
• W2004334615 cites W2056070815 @default.
• W2004334615 cites W2070864958 @default.
• W2004334615 cites W2099256396 @default.
• W2004334615 cites W2105795226 @default.
• W2004334615 doi "https://doi.org/10.1097/00041327-200020030-00006" @default.
• W2004334615 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11001192" @default.
• W2004334615 hasPublicationYear "2000" @default.
• W2004334615 type Work @default.
• W2004334615 sameAs 2004334615 @default.
• W2004334615 citedByCount "124" @default.
• W2004334615 countsByYear W20043346152012 @default.
• W2004334615 countsByYear W20043346152013 @default.
• W2004334615 countsByYear W20043346152014 @default.
• W2004334615 countsByYear W20043346152015 @default.
• W2004334615 countsByYear W20043346152016 @default.
• W2004334615 countsByYear W20043346152017 @default.
• W2004334615 countsByYear W20043346152018 @default.
• W2004334615 countsByYear W20043346152019 @default.
• W2004334615 countsByYear W20043346152020 @default.
• W2004334615 countsByYear W20043346152021 @default.
• W2004334615 countsByYear W20043346152022 @default.
• W2004334615 countsByYear W20043346152023 @default.
• W2004334615 crossrefType "journal-article" @default.
• W2004334615 hasAuthorship W2004334615A5003537669 @default.
• W2004334615 hasAuthorship W2004334615A5013537921 @default.
• W2004334615 hasAuthorship W2004334615A5049222256 @default.
• W2004334615 hasAuthorship W2004334615A5055727790 @default.
• W2004334615 hasBestOaLocation W20043346151 @default.
• W2004334615 hasConcept C118487528 @default.
• W2004334615 hasConcept C118552586 @default.
• W2004334615 hasConcept C126322002 @default.
• W2004334615 hasConcept C141071460 @default.
• W2004334615 hasConcept C187212893 @default.
• W2004334615 hasConcept C2777056713 @default.
• W2004334615 hasConcept C2777403772 @default.
• W2004334615 hasConcept C2778233873 @default.
• W2004334615 hasConcept C2778257484 @default.
• W2004334615 hasConcept C2780837183 @default.
• W2004334615 hasConcept C2781372952 @default.
• W2004334615 hasConcept C71924100 @default.
• W2004334615 hasConceptScore W2004334615C118487528 @default.
• W2004334615 hasConceptScore W2004334615C118552586 @default.
• W2004334615 hasConceptScore W2004334615C126322002 @default.
• W2004334615 hasConceptScore W2004334615C141071460 @default.
• W2004334615 hasConceptScore W2004334615C187212893 @default.
• W2004334615 hasConceptScore W2004334615C2777056713 @default.
• W2004334615 hasConceptScore W2004334615C2777403772 @default.
• W2004334615 hasConceptScore W2004334615C2778233873 @default.
• W2004334615 hasConceptScore W2004334615C2778257484 @default.
• W2004334615 hasConceptScore W2004334615C2780837183 @default.
• W2004334615 hasConceptScore W2004334615C2781372952 @default.
• W2004334615 hasConceptScore W2004334615C71924100 @default.
• W2004334615 hasIssue "3" @default.
• W2004334615 hasLocation W20043346151 @default.
• W2004334615 hasLocation W20043346152 @default.
• W2004334615 hasLocation W20043346153 @default.
• W2004334615 hasOpenAccess W2004334615 @default.
• W2004334615 hasPrimaryLocation W20043346151 @default.
• W2004334615 hasRelatedWork W2004334615 @default.
• W2004334615 hasRelatedWork W2035877471 @default.
• W2004334615 hasRelatedWork W2124154990 @default.
• W2004334615 hasRelatedWork W2341581923 @default.
• W2004334615 hasRelatedWork W2520124436 @default.
• W2004334615 hasRelatedWork W3089735243 @default.
• W2004334615 hasRelatedWork W3118969891 @default.
• W2004334615 hasRelatedWork W4224291888 @default.
• W2004334615 hasRelatedWork W4312080844 @default.
• W2004334615 hasRelatedWork W99108903 @default.
• W2004334615 hasVolume "20" @default.
• W2004334615 isParatext "false" @default.
• W2004334615 isRetracted "false" @default.
• W2004334615 magId "2004334615" @default.
• W2004334615 workType "article" @default.