FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004334938> ?p ?o ?g. }

• W2004334938 endingPage "3166" @default.
• W2004334938 startingPage "3159" @default.
• W2004334938 abstract "Curcumin has anti-oxidative activity. In view of the increasing evidence for a biochemical link between increased oxidative stress and reduced bone density we hypothesized that curcumin might increase bone density by elevating antioxidant activity in some target cell type. We measured bone density by Micro-CT, enzyme expression levels by quantitative PCR or enzyme activity, and osteoclast (OC) formation by tartrate-resistant acid phosphatase staining. The bone mineral density of the femurs of curcumin-administered mice was significantly higher than that of vehicle-treated mice after ovariectomy (OVX) and this was accompanied by reduced amounts of serum collagen-type I fragments, which are markers of bone resorption. Curcumin suppressed OC formation by increasing receptor activator of nuclear factor-κB ligand (RANKL)-induced glutathione peroxidase-1, and reversed the stimulatory effect of homocysteine, a known H2O2 generator, on OC formation by restoring Gpx activity. Curcumin generated an aberrant RANKL signal characterized by reduced expression of nuclear factor of activated T cells 2 (NFAT2) and attenuated activation of mitogen-activated protein kinases (ERK, JNK, and p38). Curcumin thus inhibited OVX-induced bone loss, at least in part by reducing osteoclastogenesis as a result of increased antioxidant activity and impaired RANKL signaling. These findings suggest that bone loss associated with estrogen deficiency could be attenuated by curcumin administration. J. Cell. Biochem. 112: 3159–3166, 2011. © 2011 Wiley Periodicals, Inc." @default.
• W2004334938 created "2016-06-24" @default.
• W2004334938 creator A5016798069 @default.
• W2004334938 creator A5024587073 @default.
• W2004334938 creator A5029186698 @default.
• W2004334938 creator A5043423557 @default.
• W2004334938 creator A5046521287 @default.
• W2004334938 creator A5047005362 @default.
• W2004334938 creator A5064297397 @default.
• W2004334938 creator A5073113236 @default.
• W2004334938 creator A5075599856 @default.
• W2004334938 creator A5090068470 @default.
• W2004334938 date "2011-10-15" @default.
• W2004334938 modified "2023-10-16" @default.
• W2004334938 title "Curcumin protects against ovariectomy-induced bone loss and decreases osteoclastogenesis" @default.
• W2004334938 cites W1520951628 @default.
• W2004334938 cites W1534645474 @default.
• W2004334938 cites W1803753513 @default.
• W2004334938 cites W1965940007 @default.
• W2004334938 cites W1971408242 @default.
• W2004334938 cites W1972179974 @default.
• W2004334938 cites W1981464232 @default.
• W2004334938 cites W1988725524 @default.
• W2004334938 cites W2000321539 @default.
• W2004334938 cites W2002831974 @default.
• W2004334938 cites W2011710975 @default.
• W2004334938 cites W2017372504 @default.
• W2004334938 cites W2017884068 @default.
• W2004334938 cites W2022146837 @default.
• W2004334938 cites W2035149684 @default.
• W2004334938 cites W2040986717 @default.
• W2004334938 cites W2042577535 @default.
• W2004334938 cites W2044147730 @default.
• W2004334938 cites W2053516334 @default.
• W2004334938 cites W2055377154 @default.
• W2004334938 cites W2056746663 @default.
• W2004334938 cites W2057523433 @default.
• W2004334938 cites W2059413260 @default.
• W2004334938 cites W2066365078 @default.
• W2004334938 cites W2077164311 @default.
• W2004334938 cites W2081647439 @default.
• W2004334938 cites W2148831997 @default.
• W2004334938 cites W2150525915 @default.
• W2004334938 cites W2154350322 @default.
• W2004334938 cites W2156156861 @default.
• W2004334938 cites W4243285955 @default.
• W2004334938 cites W4247859086 @default.
• W2004334938 cites W4256054685 @default.
• W2004334938 doi "https://doi.org/10.1002/jcb.23242" @default.
• W2004334938 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21732406" @default.
• W2004334938 hasPublicationYear "2011" @default.
• W2004334938 type Work @default.
• W2004334938 sameAs 2004334938 @default.
• W2004334938 citedByCount "68" @default.
• W2004334938 countsByYear W20043349382012 @default.
• W2004334938 countsByYear W20043349382013 @default.
• W2004334938 countsByYear W20043349382014 @default.
• W2004334938 countsByYear W20043349382015 @default.
• W2004334938 countsByYear W20043349382016 @default.
• W2004334938 countsByYear W20043349382017 @default.
• W2004334938 countsByYear W20043349382018 @default.
• W2004334938 countsByYear W20043349382019 @default.
• W2004334938 countsByYear W20043349382020 @default.
• W2004334938 countsByYear W20043349382021 @default.
• W2004334938 countsByYear W20043349382022 @default.
• W2004334938 countsByYear W20043349382023 @default.
• W2004334938 crossrefType "journal-article" @default.
• W2004334938 hasAuthorship W2004334938A5016798069 @default.
• W2004334938 hasAuthorship W2004334938A5024587073 @default.
• W2004334938 hasAuthorship W2004334938A5029186698 @default.
• W2004334938 hasAuthorship W2004334938A5043423557 @default.
• W2004334938 hasAuthorship W2004334938A5046521287 @default.
• W2004334938 hasAuthorship W2004334938A5047005362 @default.
• W2004334938 hasAuthorship W2004334938A5064297397 @default.
• W2004334938 hasAuthorship W2004334938A5073113236 @default.
• W2004334938 hasAuthorship W2004334938A5075599856 @default.
• W2004334938 hasAuthorship W2004334938A5090068470 @default.
• W2004334938 hasConcept C126322002 @default.
• W2004334938 hasConcept C134018914 @default.
• W2004334938 hasConcept C170493617 @default.
• W2004334938 hasConcept C185592680 @default.
• W2004334938 hasConcept C2775838275 @default.
• W2004334938 hasConcept C2776033226 @default.
• W2004334938 hasConcept C2776151105 @default.
• W2004334938 hasConcept C2778250585 @default.
• W2004334938 hasConcept C2778760513 @default.
• W2004334938 hasConcept C2779428903 @default.
• W2004334938 hasConcept C55493867 @default.
• W2004334938 hasConcept C57074206 @default.
• W2004334938 hasConcept C62478195 @default.
• W2004334938 hasConcept C673006 @default.
• W2004334938 hasConcept C71924100 @default.
• W2004334938 hasConcept C88045685 @default.
• W2004334938 hasConceptScore W2004334938C126322002 @default.
• W2004334938 hasConceptScore W2004334938C134018914 @default.
• W2004334938 hasConceptScore W2004334938C170493617 @default.
• W2004334938 hasConceptScore W2004334938C185592680 @default.
• W2004334938 hasConceptScore W2004334938C2775838275 @default.

• next