FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004336750> ?p ?o ?g. }

• W2004336750 endingPage "475" @default.
• W2004336750 startingPage "471" @default.
• W2004336750 abstract "Invading microbes are detected and ingested by white blood cells known as phagocytes. To do this they must distinguish between soluble microbe-derived components, such as pieces of cell wall, and the particulate microbes themselves. A study of the action of Dectin-1, an innate immune receptor that detects invading fungal pathogens, shows that although the receptor binds to both soluble and particulate cell-wall β-glucans, its activation is restricted to sites of contact with fungal cell walls by the formation of 'phagocytic synapses'. The phagocytic synapse provides a mechanistic model for the specific detection of ligands associated with a microbial surface, as opposed to those released from microbes at a distance. Innate immune cells must be able to distinguish between direct binding to microbes and detection of components shed from the surface of microbes located at a distance. Dectin-1 (also known as CLEC7A) is a pattern-recognition receptor expressed by myeloid phagocytes (macrophages, dendritic cells and neutrophils) that detects β-glucans in fungal cell walls and triggers direct cellular antimicrobial activity, including phagocytosis and production of reactive oxygen species (ROS)1,2. In contrast to inflammatory responses stimulated upon detection of soluble ligands by other pattern-recognition receptors, such as Toll-like receptors (TLRs), these responses are only useful when a cell comes into direct contact with a microbe and must not be spuriously activated by soluble stimuli. In this study we show that, despite its ability to bind both soluble and particulate β-glucan polymers, Dectin-1 signalling is only activated by particulate β-glucans, which cluster the receptor in synapse-like structures from which regulatory tyrosine phosphatases CD45 and CD148 (also known as PTPRC and PTPRJ, respectively) are excluded (Supplementary Fig. 1). The ‘phagocytic synapse’ now provides a model mechanism by which innate immune receptors can distinguish direct microbial contact from detection of microbes at a distance, thereby initiating direct cellular antimicrobial responses only when they are required." @default.
• W2004336750 created "2016-06-24" @default.
• W2004336750 creator A5008633109 @default.
• W2004336750 creator A5017576585 @default.
• W2004336750 creator A5018822912 @default.
• W2004336750 creator A5025784409 @default.
• W2004336750 creator A5029306276 @default.
• W2004336750 creator A5036374935 @default.
• W2004336750 creator A5042050280 @default.
• W2004336750 creator A5050836076 @default.
• W2004336750 creator A5052799364 @default.
• W2004336750 creator A5069460649 @default.
• W2004336750 creator A5070661384 @default.
• W2004336750 creator A5078991414 @default.
• W2004336750 creator A5087393823 @default.
• W2004336750 date "2011-04-01" @default.
• W2004336750 modified "2023-10-18" @default.
• W2004336750 title "Activation of the innate immune receptor Dectin-1 upon formation of a ‘phagocytic synapse’" @default.
• W2004336750 cites W1563034495 @default.
• W2004336750 cites W1894059737 @default.
• W2004336750 cites W1897255091 @default.
• W2004336750 cites W1988630756 @default.
• W2004336750 cites W1988822418 @default.
• W2004336750 cites W2010797082 @default.
• W2004336750 cites W2060938552 @default.
• W2004336750 cites W2066222426 @default.
• W2004336750 cites W2071165514 @default.
• W2004336750 cites W2101524137 @default.
• W2004336750 cites W2103322081 @default.
• W2004336750 cites W2107531246 @default.
• W2004336750 cites W2114876320 @default.
• W2004336750 cites W2126924404 @default.
• W2004336750 cites W2127424425 @default.
• W2004336750 cites W2130699389 @default.
• W2004336750 cites W2135335347 @default.
• W2004336750 cites W2140333814 @default.
• W2004336750 cites W2143498880 @default.
• W2004336750 cites W2146545211 @default.
• W2004336750 cites W2150753599 @default.
• W2004336750 cites W2157095212 @default.
• W2004336750 cites W2158373279 @default.
• W2004336750 cites W2170191276 @default.
• W2004336750 doi "https://doi.org/10.1038/nature10071" @default.
• W2004336750 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3084546" @default.
• W2004336750 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21525931" @default.
• W2004336750 hasPublicationYear "2011" @default.
• W2004336750 type Work @default.
• W2004336750 sameAs 2004336750 @default.
• W2004336750 citedByCount "664" @default.
• W2004336750 countsByYear W20043367502012 @default.
• W2004336750 countsByYear W20043367502013 @default.
• W2004336750 countsByYear W20043367502014 @default.
• W2004336750 countsByYear W20043367502015 @default.
• W2004336750 countsByYear W20043367502016 @default.
• W2004336750 countsByYear W20043367502017 @default.
• W2004336750 countsByYear W20043367502018 @default.
• W2004336750 countsByYear W20043367502019 @default.
• W2004336750 countsByYear W20043367502020 @default.
• W2004336750 countsByYear W20043367502021 @default.
• W2004336750 countsByYear W20043367502022 @default.
• W2004336750 countsByYear W20043367502023 @default.
• W2004336750 crossrefType "journal-article" @default.
• W2004336750 hasAuthorship W2004336750A5008633109 @default.
• W2004336750 hasAuthorship W2004336750A5017576585 @default.
• W2004336750 hasAuthorship W2004336750A5018822912 @default.
• W2004336750 hasAuthorship W2004336750A5025784409 @default.
• W2004336750 hasAuthorship W2004336750A5029306276 @default.
• W2004336750 hasAuthorship W2004336750A5036374935 @default.
• W2004336750 hasAuthorship W2004336750A5042050280 @default.
• W2004336750 hasAuthorship W2004336750A5050836076 @default.
• W2004336750 hasAuthorship W2004336750A5052799364 @default.
• W2004336750 hasAuthorship W2004336750A5069460649 @default.
• W2004336750 hasAuthorship W2004336750A5070661384 @default.
• W2004336750 hasAuthorship W2004336750A5078991414 @default.
• W2004336750 hasAuthorship W2004336750A5087393823 @default.
• W2004336750 hasBestOaLocation W20043367502 @default.
• W2004336750 hasConcept C111289621 @default.
• W2004336750 hasConcept C136449434 @default.
• W2004336750 hasConcept C1491633281 @default.
• W2004336750 hasConcept C160448771 @default.
• W2004336750 hasConcept C170493617 @default.
• W2004336750 hasConcept C19317047 @default.
• W2004336750 hasConcept C203014093 @default.
• W2004336750 hasConcept C2776090121 @default.
• W2004336750 hasConcept C55493867 @default.
• W2004336750 hasConcept C86803240 @default.
• W2004336750 hasConcept C8891405 @default.
• W2004336750 hasConcept C89423630 @default.
• W2004336750 hasConcept C95444343 @default.
• W2004336750 hasConcept C9756297 @default.
• W2004336750 hasConceptScore W2004336750C111289621 @default.
• W2004336750 hasConceptScore W2004336750C136449434 @default.
• W2004336750 hasConceptScore W2004336750C1491633281 @default.
• W2004336750 hasConceptScore W2004336750C160448771 @default.
• W2004336750 hasConceptScore W2004336750C170493617 @default.
• W2004336750 hasConceptScore W2004336750C19317047 @default.
• W2004336750 hasConceptScore W2004336750C203014093 @default.
• W2004336750 hasConceptScore W2004336750C2776090121 @default.

• next