Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004337545> ?p ?o ?g. }
- W2004337545 endingPage "5218" @default.
- W2004337545 startingPage "5205" @default.
- W2004337545 abstract "Dermal infiltration of T cells is an important step in the onset and progression of immune-mediated skin diseases such as psoriasis; however, it is not known whether epidermal factors play a primary role in the development of these diseases. Here, we determined that the prodifferentiation transcription factor grainyhead-like 3 (GRHL3), which is essential during epidermal development, is dispensable for adult skin homeostasis, but required for barrier repair after adult epidermal injury. Consistent with activation of a GRHL3-regulated repair pathway in psoriasis, we found that GRHL3 is upregulated in lesional skin and binds known epidermal differentiation gene targets. Using an imiquimod-induced model of immune-mediated epidermal hyperplasia, we found that mice lacking GRHL3 have an exacerbated epidermal damage response, greater sensitivity to disease induction, delayed resolution of epidermal lesions, and resistance to anti-IL-22 therapy compared with WT animals. ChIP-Seq and gene expression profiling of murine skin revealed that while GRHL3 regulates differentiation pathways both during development and during repair from immune-mediated damage, it targets distinct sets of genes in the 2 processes. In particular, GRHL3 suppressed a number of alarmin and other proinflammatory genes after immune injury. This study identifies a GRHL3-regulated epidermal barrier repair pathway that suppresses disease initiation and helps resolve existing lesions in immune-mediated epidermal hyperplasia." @default.
- W2004337545 created "2016-06-24" @default.
- W2004337545 creator A5007661569 @default.
- W2004337545 creator A5013733586 @default.
- W2004337545 creator A5043610128 @default.
- W2004337545 creator A5058475475 @default.
- W2004337545 creator A5062288180 @default.
- W2004337545 creator A5062614823 @default.
- W2004337545 creator A5067149232 @default.
- W2004337545 creator A5083060214 @default.
- W2004337545 creator A5088813478 @default.
- W2004337545 date "2014-10-27" @default.
- W2004337545 modified "2023-10-11" @default.
- W2004337545 title "A GRHL3-regulated repair pathway suppresses immune-mediated epidermal hyperplasia" @default.
- W2004337545 cites W1513329088 @default.
- W2004337545 cites W1939997832 @default.
- W2004337545 cites W1967164347 @default.
- W2004337545 cites W1967937896 @default.
- W2004337545 cites W1969274790 @default.
- W2004337545 cites W1974517068 @default.
- W2004337545 cites W1974920067 @default.
- W2004337545 cites W1976291381 @default.
- W2004337545 cites W1976580145 @default.
- W2004337545 cites W1981034346 @default.
- W2004337545 cites W1981177225 @default.
- W2004337545 cites W1998975791 @default.
- W2004337545 cites W2002673451 @default.
- W2004337545 cites W2003425690 @default.
- W2004337545 cites W2004741217 @default.
- W2004337545 cites W2004937659 @default.
- W2004337545 cites W2007692648 @default.
- W2004337545 cites W2008086119 @default.
- W2004337545 cites W2011566712 @default.
- W2004337545 cites W2014544550 @default.
- W2004337545 cites W2014677321 @default.
- W2004337545 cites W2017194300 @default.
- W2004337545 cites W2029373728 @default.
- W2004337545 cites W2031721857 @default.
- W2004337545 cites W2032693037 @default.
- W2004337545 cites W2035272369 @default.
- W2004337545 cites W2038621043 @default.
- W2004337545 cites W2042141383 @default.
- W2004337545 cites W2042672171 @default.
- W2004337545 cites W2045113343 @default.
- W2004337545 cites W2045255741 @default.
- W2004337545 cites W2049572499 @default.
- W2004337545 cites W2049701162 @default.
- W2004337545 cites W2051004598 @default.
- W2004337545 cites W2054230488 @default.
- W2004337545 cites W2063825509 @default.
- W2004337545 cites W2065481771 @default.
- W2004337545 cites W2068176013 @default.
- W2004337545 cites W2070517981 @default.
- W2004337545 cites W2074062652 @default.
- W2004337545 cites W2076764173 @default.
- W2004337545 cites W2080697619 @default.
- W2004337545 cites W2082280403 @default.
- W2004337545 cites W2083530614 @default.
- W2004337545 cites W2084715486 @default.
- W2004337545 cites W2089208435 @default.
- W2004337545 cites W2097466966 @default.
- W2004337545 cites W2099731455 @default.
- W2004337545 cites W2102889851 @default.
- W2004337545 cites W2107638340 @default.
- W2004337545 cites W2118258530 @default.
- W2004337545 cites W2118426776 @default.
- W2004337545 cites W2121226849 @default.
- W2004337545 cites W2121900420 @default.
- W2004337545 cites W2122416344 @default.
- W2004337545 cites W2123342417 @default.
- W2004337545 cites W2124659501 @default.
- W2004337545 cites W2124896761 @default.
- W2004337545 cites W2124985265 @default.
- W2004337545 cites W2127661753 @default.
- W2004337545 cites W2132041082 @default.
- W2004337545 cites W2132650229 @default.
- W2004337545 cites W2138660441 @default.
- W2004337545 cites W2140148196 @default.
- W2004337545 cites W2145677448 @default.
- W2004337545 cites W2145834141 @default.
- W2004337545 cites W2146042781 @default.
- W2004337545 cites W2147701916 @default.
- W2004337545 cites W2155582127 @default.
- W2004337545 cites W2160072626 @default.
- W2004337545 cites W2164880184 @default.
- W2004337545 cites W2171783560 @default.
- W2004337545 cites W2171808845 @default.
- W2004337545 cites W2335310975 @default.
- W2004337545 cites W2558692177 @default.
- W2004337545 doi "https://doi.org/10.1172/jci77138" @default.
- W2004337545 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4348962" @default.
- W2004337545 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25347468" @default.
- W2004337545 hasPublicationYear "2014" @default.
- W2004337545 type Work @default.
- W2004337545 sameAs 2004337545 @default.
- W2004337545 citedByCount "44" @default.
- W2004337545 countsByYear W20043375452016 @default.
- W2004337545 countsByYear W20043375452017 @default.