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• W2004339915 abstract "The involvement of the mitochondrial permeability transition pore (PTP) in the responses of mitochondria from adjuvant-induced arthritic rats to Ca2+ addition was investigated. The respiratory activity, the Ca2+-induced osmotic swelling and the electrophoretic 45Ca2+ uptake were evaluated in the absence and in the presence of cyclosporin A (CsA), a well-known inhibitor of the mitochondrial PTP. The Ca2+-induced mitochondrial permeability transition (MPT) process occurred in mitochondria from arthritic rats even in the presence of a low Ca2+ concentration. Whereas in the normal condition, the Ca2+-induced uncoupling of oxidative phosphorylation and osmotic swelling was observed in the presence of 10 or 20 µM Ca2+ concentration, in the arthritic condition, these events occurred at 1.0 µM concentration. In addition, mitochondria from arthritic rats presented an impaired ability to accumulate 45Ca2+. All these effects were completely prevented by the administration of CsA. The results of the present study suggest that the higher sensitivity of mitochondria from arthritic rats to Ca2+-induced MPT may be an important factor in the pathogenesis of the arthritis disease. Copyright © 2008 John Wiley & Sons, Ltd." @default.
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• W2004339915 date "2008-01-01" @default.
• W2004339915 modified "2023-10-02" @default.
• W2004339915 title "Changes in calcium-dependent membrane permeability properties in mitochondria of livers from arthritic rats" @default.
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• W2004339915 doi "https://doi.org/10.1002/cbf.1461" @default.
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