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- W2004341008 abstract "Promising anticancer compounds of the type 1,6-disubstituted 4,5,6,7-tetrahydropyrazolo[3,4-c]pyridin-7-ones were identified. The target compounds were readily synthesized in a large scale via a sequence of reactions starting from the commercially available primary amines. Their in vitro anti-proliferative activity has been evaluated on prostate (DU-145), colon (HT-29 and HCT-116) and melanoma (A375P) human cancer cell lines. The relationships between the structure and the anticancer activity, covering all tested cancer cell lines, revealed that the compound 5c with 2,4-dimethylphenyl substituent at <TEX>$R^2$</TEX> was the most potent with the <TEX>$IC_{50}$</TEX> values in the range as low as 0.16 to <TEX>$0.40{mu}M$</TEX>." @default.
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- W2004341008 date "2012-02-20" @default.
- W2004341008 modified "2023-09-27" @default.
- W2004341008 title "Synthesis of 1,6-Disubstituted 4,5,6,7-Tetrahydropyrazolo[3,4-c]pyridin-7-one Derivatives and Evaluation of Their Anticancer Activity" @default.
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- W2004341008 doi "https://doi.org/10.5012/bkcs.2012.33.2.647" @default.
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