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- W2004341421 endingPage "161" @default.
- W2004341421 startingPage "153" @default.
- W2004341421 abstract "The somatic Sertoli cell plays an essential role in embryonic determination of male somatic sex and in spermatogenesis during adult life. One individual Sertoli cell supplies a clone of developing germ cells with nutrients and growth factors and it is well established that the number of Sertoli cells present is closely correlated to both testicular size and sperm output. Sertoli cells continue to proliferate and differentiate until the beginning of puberty, when they cease dividing and start nursing the germ cells. At this point in time, the future capacity of the testis for sperm production has thus been determined. Prior to puberty the Sertoli cells are immature and differ considerably with respect to morphology and biochemical activity from the mature cell. The several investigations that have focused on hormonal and paracrine regulation of the functions of the mature cell are reviewed here, but the mechanisms underlying the maturation and general maintenance of well-functioning Sertoli cells remain obscure. An alarming decline in male reproductive health has been observed in several Western countries during recent decades. Disturbance of Sertoli cell differentiation is thought to be involved in the pathogenesis of both a poor sperm count and testicular cancer. It is speculated that environmental agents that disrupt the estrogenic/androgenic balance in the testis may play a role in this connection." @default.
- W2004341421 created "2016-06-24" @default.
- W2004341421 creator A5046023727 @default.
- W2004341421 creator A5079465039 @default.
- W2004341421 date "2006-01-01" @default.
- W2004341421 modified "2023-10-17" @default.
- W2004341421 title "The Sertoli Cell – A Hormonal Target and ‘Super’ Nurse for Germ Cells That Determines Testicular Size" @default.
- W2004341421 cites W1522869477 @default.
- W2004341421 cites W1572551760 @default.
- W2004341421 cites W1574586108 @default.
- W2004341421 cites W1788268544 @default.
- W2004341421 cites W184416390 @default.
- W2004341421 cites W1928106516 @default.
- W2004341421 cites W1963785171 @default.
- W2004341421 cites W1965511499 @default.
- W2004341421 cites W1965721340 @default.
- W2004341421 cites W1967279915 @default.
- W2004341421 cites W1969893053 @default.
- W2004341421 cites W1970614793 @default.
- W2004341421 cites W1971858261 @default.
- W2004341421 cites W1972196325 @default.
- W2004341421 cites W1979438713 @default.
- W2004341421 cites W1984597756 @default.
- W2004341421 cites W1986375433 @default.
- W2004341421 cites W1989313572 @default.
- W2004341421 cites W1990207361 @default.
- W2004341421 cites W1994130571 @default.
- W2004341421 cites W1996202698 @default.
- W2004341421 cites W2002281751 @default.
- W2004341421 cites W2003351700 @default.
- W2004341421 cites W2006044949 @default.
- W2004341421 cites W2006338836 @default.
- W2004341421 cites W2011118373 @default.
- W2004341421 cites W2012332201 @default.
- W2004341421 cites W2012682962 @default.
- W2004341421 cites W2015963173 @default.
- W2004341421 cites W2019983300 @default.
- W2004341421 cites W2029804435 @default.
- W2004341421 cites W2031311121 @default.
- W2004341421 cites W2034382620 @default.
- W2004341421 cites W2034417567 @default.
- W2004341421 cites W2037437678 @default.
- W2004341421 cites W2040509452 @default.
- W2004341421 cites W2042128830 @default.
- W2004341421 cites W2045241942 @default.
- W2004341421 cites W2045741765 @default.
- W2004341421 cites W2047096573 @default.
- W2004341421 cites W2048033000 @default.
- W2004341421 cites W2048491470 @default.
- W2004341421 cites W2050436992 @default.
- W2004341421 cites W2051851402 @default.
- W2004341421 cites W2052345713 @default.
- W2004341421 cites W2059337926 @default.
- W2004341421 cites W2063843231 @default.
- W2004341421 cites W2065599061 @default.
- W2004341421 cites W2067711610 @default.
- W2004341421 cites W2070282026 @default.
- W2004341421 cites W2070731858 @default.
- W2004341421 cites W2073686351 @default.
- W2004341421 cites W2074094477 @default.
- W2004341421 cites W2074859762 @default.
- W2004341421 cites W2076873141 @default.
- W2004341421 cites W2078395305 @default.
- W2004341421 cites W2083172003 @default.
- W2004341421 cites W2090782553 @default.
- W2004341421 cites W2093697472 @default.
- W2004341421 cites W2097198261 @default.
- W2004341421 cites W2098400794 @default.
- W2004341421 cites W2098737213 @default.
- W2004341421 cites W2099415229 @default.
- W2004341421 cites W2100761457 @default.
- W2004341421 cites W2103191975 @default.
- W2004341421 cites W2114648205 @default.
- W2004341421 cites W2116653947 @default.
- W2004341421 cites W2122693798 @default.
- W2004341421 cites W2123135255 @default.
- W2004341421 cites W2129702891 @default.
- W2004341421 cites W2135061219 @default.
- W2004341421 cites W2136306204 @default.
- W2004341421 cites W2136306240 @default.
- W2004341421 cites W2141577342 @default.
- W2004341421 cites W2145047354 @default.
- W2004341421 cites W2147214298 @default.
- W2004341421 cites W2154094989 @default.
- W2004341421 cites W2157857817 @default.
- W2004341421 cites W2157999278 @default.
- W2004341421 cites W2158446846 @default.
- W2004341421 cites W2159630741 @default.
- W2004341421 cites W2162588777 @default.
- W2004341421 cites W2164228490 @default.
- W2004341421 cites W2166481218 @default.
- W2004341421 cites W2168915414 @default.
- W2004341421 cites W2170116261 @default.
- W2004341421 cites W2171423639 @default.
- W2004341421 cites W217603543 @default.
- W2004341421 cites W2185253197 @default.
- W2004341421 cites W2321613759 @default.
- W2004341421 cites W2398148798 @default.