FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004342455> ?p ?o ?g. }

• W2004342455 endingPage "23" @default.
• W2004342455 startingPage "17" @default.
• W2004342455 abstract "Several lines of evidence suggest that malonyl-CoA in the hypothalamus plays an important role in monitoring and modulating body energy balance. In fasted state the level of malonyl-CoA concentration significantly decreases. Simultaneously, orexigenic neuropeptides (NPY – neuropeptide Y, AgRP – agouti-related peptide) genes are expressed at high level, whereas anorexigenic neuropeptides (CART – cocaine-and amphetamine-regulated transcript, POMC – proopiomelanocortin) genes are expressed at low level. When food intake resumes, opposite effect is observed. This study examined the effect of prolonged food restriction, common in humans trying to lose body weight on expression of orexigenic and anorexigenic neuropetides genes and on malonyl-CoA content in rat whole hypothalamus. We observed an increase of NPY and AgRP mRNA levels in hypothalamus of rats kept on 30 days-long food restriction (50% of the amount of food consumed by controls). Simultaneously, a decrease of CART and POMC mRNA levels occurred. Refeeding caused a decrease in NPY and POMC mRNA levels without effect on AgRP and CART mRNA. Surprisingly, both prolonged food restriction and food restriction/refeeding caused the increase of malonyl-CoA level in whole hypothalamus. In contrast, fasting for 24 h caused the decrease of malonyl-CoA level, which was associated with the up-regulation of NPY and AgRP genes expression and down-regulation of CART and POMC genes expression. After refeeding opposite effect was observed. These results indicate that prolonged food restriction and acute fasting, conditions in which energy expenditure exceeds intake, differentially affect malonyl-CoA concentration and similarly affect orexigenic and anorexigenic neuropeptide genes expression in whole rat hypothalamus." @default.
• W2004342455 created "2016-06-24" @default.
• W2004342455 creator A5010299033 @default.
• W2004342455 creator A5011283136 @default.
• W2004342455 creator A5016638554 @default.
• W2004342455 creator A5018356274 @default.
• W2004342455 creator A5021104852 @default.
• W2004342455 creator A5043134796 @default.
• W2004342455 creator A5057414547 @default.
• W2004342455 creator A5064089380 @default.
• W2004342455 creator A5073363845 @default.
• W2004342455 date "2010-02-01" @default.
• W2004342455 modified "2023-10-07" @default.
• W2004342455 title "Differential effect of prolonged food restriction and fasting on hypothalamic malonyl-CoA concentration and expression of orexigenic and anorexigenic neuropeptides genes in rats" @default.
• W2004342455 cites W1983394635 @default.
• W2004342455 cites W2007444562 @default.
• W2004342455 cites W2016877878 @default.
• W2004342455 cites W2020843850 @default.
• W2004342455 cites W2029619804 @default.
• W2004342455 cites W2030271926 @default.
• W2004342455 cites W2034231070 @default.
• W2004342455 cites W2038008361 @default.
• W2004342455 cites W2039048217 @default.
• W2004342455 cites W2041624270 @default.
• W2004342455 cites W2042764090 @default.
• W2004342455 cites W2049454720 @default.
• W2004342455 cites W2060825744 @default.
• W2004342455 cites W2061632377 @default.
• W2004342455 cites W2071855979 @default.
• W2004342455 cites W2072982982 @default.
• W2004342455 cites W2086719628 @default.
• W2004342455 cites W2088563900 @default.
• W2004342455 cites W2093273210 @default.
• W2004342455 cites W2102521284 @default.
• W2004342455 cites W2107277218 @default.
• W2004342455 cites W2125745486 @default.
• W2004342455 cites W2131463221 @default.
• W2004342455 cites W2133384738 @default.
• W2004342455 cites W2147043321 @default.
• W2004342455 cites W2903905960 @default.
• W2004342455 cites W4231314870 @default.
• W2004342455 cites W4294216491 @default.
• W2004342455 doi "https://doi.org/10.1016/j.npep.2009.11.005" @default.
• W2004342455 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20004973" @default.
• W2004342455 hasPublicationYear "2010" @default.
• W2004342455 type Work @default.
• W2004342455 sameAs 2004342455 @default.
• W2004342455 citedByCount "28" @default.
• W2004342455 countsByYear W20043424552012 @default.
• W2004342455 countsByYear W20043424552013 @default.
• W2004342455 countsByYear W20043424552014 @default.
• W2004342455 countsByYear W20043424552015 @default.
• W2004342455 countsByYear W20043424552017 @default.
• W2004342455 countsByYear W20043424552018 @default.
• W2004342455 countsByYear W20043424552020 @default.
• W2004342455 countsByYear W20043424552021 @default.
• W2004342455 countsByYear W20043424552022 @default.
• W2004342455 countsByYear W20043424552023 @default.
• W2004342455 crossrefType "journal-article" @default.
• W2004342455 hasAuthorship W2004342455A5010299033 @default.
• W2004342455 hasAuthorship W2004342455A5011283136 @default.
• W2004342455 hasAuthorship W2004342455A5016638554 @default.
• W2004342455 hasAuthorship W2004342455A5018356274 @default.
• W2004342455 hasAuthorship W2004342455A5021104852 @default.
• W2004342455 hasAuthorship W2004342455A5043134796 @default.
• W2004342455 hasAuthorship W2004342455A5057414547 @default.
• W2004342455 hasAuthorship W2004342455A5064089380 @default.
• W2004342455 hasAuthorship W2004342455A5073363845 @default.
• W2004342455 hasConcept C118303440 @default.
• W2004342455 hasConcept C126322002 @default.
• W2004342455 hasConcept C127413603 @default.
• W2004342455 hasConcept C134018914 @default.
• W2004342455 hasConcept C170493617 @default.
• W2004342455 hasConcept C2777003273 @default.
• W2004342455 hasConcept C2777205416 @default.
• W2004342455 hasConcept C2777275308 @default.
• W2004342455 hasConcept C2780278141 @default.
• W2004342455 hasConcept C2781309135 @default.
• W2004342455 hasConcept C71924100 @default.
• W2004342455 hasConcept C78519656 @default.
• W2004342455 hasConcept C86803240 @default.
• W2004342455 hasConcept C93984277 @default.
• W2004342455 hasConceptScore W2004342455C118303440 @default.
• W2004342455 hasConceptScore W2004342455C126322002 @default.
• W2004342455 hasConceptScore W2004342455C127413603 @default.
• W2004342455 hasConceptScore W2004342455C134018914 @default.
• W2004342455 hasConceptScore W2004342455C170493617 @default.
• W2004342455 hasConceptScore W2004342455C2777003273 @default.
• W2004342455 hasConceptScore W2004342455C2777205416 @default.
• W2004342455 hasConceptScore W2004342455C2777275308 @default.
• W2004342455 hasConceptScore W2004342455C2780278141 @default.
• W2004342455 hasConceptScore W2004342455C2781309135 @default.
• W2004342455 hasConceptScore W2004342455C71924100 @default.
• W2004342455 hasConceptScore W2004342455C78519656 @default.
• W2004342455 hasConceptScore W2004342455C86803240 @default.
• W2004342455 hasConceptScore W2004342455C93984277 @default.
• W2004342455 hasIssue "1" @default.
• W2004342455 hasLocation W20043424551 @default.

• next