FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004343325> ?p ?o ?g. }

• W2004343325 endingPage "E1032" @default.
• W2004343325 startingPage "E1022" @default.
• W2004343325 abstract "Peroxisome proliferator-activated receptors (PPARs) control energy homeostasis. In this study, we showed that farnesol, a naturally occurring ligand of PPARs, could ameliorate metabolic diseases. Obese KK-Ay mice fed a high-fat diet (HFD) containing 0.5% farnesol showed significantly decreased serum glucose level, glucosuria incidence, and hepatic triglyceride contents. Farnesol-containing HFD upregulated the mRNA expressions of PPARα target genes involved in fatty acid oxidation in the liver. On the other hand, farnesol was not effective in upregulating the mRNA expressions of PPARγ target genes in white adipose tissues. Experiments using PPARα-deficient [(-/-)] mice revealed that the upregulation of fatty acid oxidation-related genes required PPARα function, but the suppression of hepatic triglyceride accumulation was partially PPARα-dependent. In hepatocytes isolated from the wild-type and PPARα (-/-) mice, farnesol suppressed triglyceride synthesis. In luciferase assay, farnesol activated both PPARα and the farnesoid X receptor (FXR) at similar concentrations. Moreover, farnesol increased the mRNA expression level of a small heterodimer partner known as one of the FXR target genes and decreased those of sterol regulatory element-binding protein-1c and fatty acid synthase in both the wild-type and PPARα (-/-) hepatocytes. These findings suggest that farnesol could improve metabolic abnormalities in mice via both PPARα-dependent and -independent pathways and that the activation of FXR by farnesol might contribute partially to the PPARα-independent hepatic triglyceride content-lowering effect. To our knowledge, this is the first study on the effect of the dual activators of PPARα and FXR on obesity-induced metabolic disorders." @default.
• W2004343325 created "2016-06-24" @default.
• W2004343325 creator A5000852788 @default.
• W2004343325 creator A5002960598 @default.
• W2004343325 creator A5007426726 @default.
• W2004343325 creator A5010450102 @default.
• W2004343325 creator A5010502943 @default.
• W2004343325 creator A5018235068 @default.
• W2004343325 creator A5022150740 @default.
• W2004343325 creator A5023241394 @default.
• W2004343325 creator A5027655875 @default.
• W2004343325 creator A5038235227 @default.
• W2004343325 creator A5047196134 @default.
• W2004343325 creator A5052434732 @default.
• W2004343325 creator A5066125430 @default.
• W2004343325 creator A5072650136 @default.
• W2004343325 creator A5079755488 @default.
• W2004343325 date "2011-11-01" @default.
• W2004343325 modified "2023-10-14" @default.
• W2004343325 title "Farnesol, an isoprenoid, improves metabolic abnormalities in mice via both PPARα-dependent and -independent pathways" @default.
• W2004343325 cites W1534052272 @default.
• W2004343325 cites W1556380106 @default.
• W2004343325 cites W1567666856 @default.
• W2004343325 cites W1603786143 @default.
• W2004343325 cites W1833280944 @default.
• W2004343325 cites W1966922165 @default.
• W2004343325 cites W1976621716 @default.
• W2004343325 cites W1979963836 @default.
• W2004343325 cites W1982027543 @default.
• W2004343325 cites W1987601141 @default.
• W2004343325 cites W1988012657 @default.
• W2004343325 cites W1989232975 @default.
• W2004343325 cites W1989687646 @default.
• W2004343325 cites W1989824965 @default.
• W2004343325 cites W2003389247 @default.
• W2004343325 cites W2012834939 @default.
• W2004343325 cites W2015508853 @default.
• W2004343325 cites W2017918116 @default.
• W2004343325 cites W2018918720 @default.
• W2004343325 cites W2021703416 @default.
• W2004343325 cites W2045223517 @default.
• W2004343325 cites W2046146399 @default.
• W2004343325 cites W2051040521 @default.
• W2004343325 cites W2053581007 @default.
• W2004343325 cites W2054563740 @default.
• W2004343325 cites W2062116874 @default.
• W2004343325 cites W2064473980 @default.
• W2004343325 cites W2065624367 @default.
• W2004343325 cites W2066417769 @default.
• W2004343325 cites W2069933276 @default.
• W2004343325 cites W2089422003 @default.
• W2004343325 cites W2092621119 @default.
• W2004343325 cites W2097294719 @default.
• W2004343325 cites W2100265114 @default.
• W2004343325 cites W2103116278 @default.
• W2004343325 cites W2105532009 @default.
• W2004343325 cites W2108315675 @default.
• W2004343325 cites W2112316124 @default.
• W2004343325 cites W2115414014 @default.
• W2004343325 cites W2117809024 @default.
• W2004343325 cites W2121496639 @default.
• W2004343325 cites W2130030488 @default.
• W2004343325 cites W2131287047 @default.
• W2004343325 cites W2134823147 @default.
• W2004343325 cites W2135985666 @default.
• W2004343325 cites W2137046761 @default.
• W2004343325 cites W2140248121 @default.
• W2004343325 cites W2141727688 @default.
• W2004343325 cites W2142415239 @default.
• W2004343325 cites W2142789398 @default.
• W2004343325 cites W2143736212 @default.
• W2004343325 cites W2146230078 @default.
• W2004343325 cites W2148824946 @default.
• W2004343325 cites W2151237225 @default.
• W2004343325 cites W2159121645 @default.
• W2004343325 cites W2163810943 @default.
• W2004343325 cites W2169270120 @default.
• W2004343325 cites W2171716790 @default.
• W2004343325 cites W2414767959 @default.
• W2004343325 doi "https://doi.org/10.1152/ajpendo.00061.2011" @default.
• W2004343325 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21862726" @default.
• W2004343325 hasPublicationYear "2011" @default.
• W2004343325 type Work @default.
• W2004343325 sameAs 2004343325 @default.
• W2004343325 citedByCount "46" @default.
• W2004343325 countsByYear W20043433252012 @default.
• W2004343325 countsByYear W20043433252013 @default.
• W2004343325 countsByYear W20043433252015 @default.
• W2004343325 countsByYear W20043433252016 @default.
• W2004343325 countsByYear W20043433252017 @default.
• W2004343325 countsByYear W20043433252018 @default.
• W2004343325 countsByYear W20043433252019 @default.
• W2004343325 countsByYear W20043433252020 @default.
• W2004343325 countsByYear W20043433252021 @default.
• W2004343325 countsByYear W20043433252022 @default.
• W2004343325 countsByYear W20043433252023 @default.
• W2004343325 crossrefType "journal-article" @default.
• W2004343325 hasAuthorship W2004343325A5000852788 @default.

• next