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• W2004343359 endingPage "8245" @default.
• W2004343359 startingPage "8238" @default.
• W2004343359 abstract "Large-conductance Ca 2+ - and voltage-activated potassium (BK Ca ) channels shape the firing pattern in many types of excitable cell through their repolarizing K + conductance. The onset and duration of the BK Ca -mediated currents typically initiated by action potentials (APs) appear to be cell-type specific and were shown to vary between 1 ms and up to a few tens of milliseconds. In recent work, we showed that reliable activation of BK Ca channels under cellular conditions is enabled by their integration into complexes with voltage-activated Ca 2+ (Cav) channels that provide Ca 2+ ions at concentrations sufficiently high (≥10 μ m ) for activation of BK Ca in the physiological voltage range. Formation of BK Ca –Cav complexes is restricted to a subset of Cav channels, Cav1.2 (L-type) and Cav2.1/2.2 (P/Q- and N-type), which differ greatly in their expression pattern and gating properties. Here, we reconstituted distinct BK Ca –Cav complexes in Xenopus oocytes and culture cells and used patch-clamp recordings to compare the functional properties of BK Ca –Cav1.2 and BK Ca –Cav2.1 complexes. Under steady-state conditions, K + currents mediated by BK Ca –Cav2.1 complexes exhibit a considerably faster rise time and reach maximum at potentials markedly more negative than complexes formed by BK Ca and Cav1.2, in line with the distinct steady-state activation and gating kinetics of the two Cav subtypes. When AP waveforms were used as a voltage command, K + currents mediated by BK Ca –Cav2.1 occurred at shorter APs and lasted longer than that of BK Ca –Cav1.2. These results demonstrate that the repolarizing K + currents through BK Ca –Cav complexes are shaped by the respective Cav subunit and that the distinct Cav channels may adapt BK Ca currents to the particular requirements of distinct types of cell." @default.
• W2004343359 created "2016-06-24" @default.
• W2004343359 creator A5034045555 @default.
• W2004343359 creator A5083310937 @default.
• W2004343359 date "2008-08-13" @default.
• W2004343359 modified "2023-10-15" @default.
• W2004343359 title "Repolarizing Responses of BK_Ca–Cav Complexes Are Distinctly Shaped by Their Cav Subunits" @default.
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• W2004343359 doi "https://doi.org/10.1523/jneurosci.2274-08.2008" @default.
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