FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004348977> ?p ?o ?g. }

• W2004348977 endingPage "62" @default.
• W2004348977 startingPage "51" @default.
• W2004348977 abstract "The T5P mutation in human γC-crystallin produces a lens cataract. Here, we have investigated the effects of the T5P mutation upon the aggregation of γC-crystallin in vitro and in transfected cells. By sedimentation assay and sucrose gradient centrifugation, the mutation significantly increased the aggregation of the protein and reduced dramatically its solubility in vitro. Similar effects were seen when T5P γC-crystallin was transfected into tissue culture cells, resulting in the formation of cytoplasmic aggregates of T5P γC-crystallin. Interestingly, the major lenticular protein chaperones, αA- and αB-crystallin, increased the solubility of the T5P γC-crystallin both in vitro and in transfected cells. More importantly, the size of the T5P γC-crystallin aggregates were also significantly reduced in the presence of the lenticular chaperones. These data therefore suggest a dual role for these chaperones in maintaining transparency in the lens. The first is that these protein chaperones increase the proportion of the soluble T5P γC-crystallin and the second is that they also reduce light scatter by reducing the aggregate size of T5P γC-crystallin. Both activities could modify the cataract phenotype and help explain the observed variability reported for identical γ-crystallin mutations, which identify cataract as a polygenic disease." @default.
• W2004348977 created "2016-06-24" @default.
• W2004348977 creator A5006497097 @default.
• W2004348977 creator A5012270222 @default.
• W2004348977 date "2006-01-01" @default.
• W2004348977 modified "2023-09-27" @default.
• W2004348977 title "Lenticular chaperones suppress the aggregation of the cataract-causing mutant T5P γC-crystallin" @default.
• W2004348977 cites W1497843695 @default.
• W2004348977 cites W1516398266 @default.
• W2004348977 cites W1564205457 @default.
• W2004348977 cites W1574357584 @default.
• W2004348977 cites W1581064972 @default.
• W2004348977 cites W1604252033 @default.
• W2004348977 cites W1851814176 @default.
• W2004348977 cites W1970999057 @default.
• W2004348977 cites W1975833079 @default.
• W2004348977 cites W1978012062 @default.
• W2004348977 cites W1978302916 @default.
• W2004348977 cites W1985026339 @default.
• W2004348977 cites W1985801436 @default.
• W2004348977 cites W1992909271 @default.
• W2004348977 cites W2003481405 @default.
• W2004348977 cites W2007402459 @default.
• W2004348977 cites W2008630986 @default.
• W2004348977 cites W2017995956 @default.
• W2004348977 cites W2040743789 @default.
• W2004348977 cites W2041739843 @default.
• W2004348977 cites W2044031095 @default.
• W2004348977 cites W2044122905 @default.
• W2004348977 cites W2045407120 @default.
• W2004348977 cites W2046185737 @default.
• W2004348977 cites W2050535582 @default.
• W2004348977 cites W2051086233 @default.
• W2004348977 cites W2056989077 @default.
• W2004348977 cites W2057033170 @default.
• W2004348977 cites W2057056702 @default.
• W2004348977 cites W2059310462 @default.
• W2004348977 cites W2060051476 @default.
• W2004348977 cites W2062660916 @default.
• W2004348977 cites W2067852794 @default.
• W2004348977 cites W2068792255 @default.
• W2004348977 cites W2084588066 @default.
• W2004348977 cites W2085775628 @default.
• W2004348977 cites W2089026017 @default.
• W2004348977 cites W2090805415 @default.
• W2004348977 cites W2092522607 @default.
• W2004348977 cites W2100837269 @default.
• W2004348977 cites W2102392672 @default.
• W2004348977 cites W2113461670 @default.
• W2004348977 cites W2113707581 @default.
• W2004348977 cites W2113850239 @default.
• W2004348977 cites W2114570698 @default.
• W2004348977 cites W2121555983 @default.
• W2004348977 cites W2125424810 @default.
• W2004348977 cites W2142276361 @default.
• W2004348977 cites W2145101544 @default.
• W2004348977 cites W2149182598 @default.
• W2004348977 cites W2149414182 @default.
• W2004348977 cites W2152957270 @default.
• W2004348977 cites W2158811619 @default.
• W2004348977 cites W2161898117 @default.
• W2004348977 cites W2170278458 @default.
• W2004348977 cites W2170444891 @default.
• W2004348977 cites W2173218272 @default.
• W2004348977 cites W2343639856 @default.
• W2004348977 cites W2396574724 @default.
• W2004348977 cites W2409558133 @default.
• W2004348977 cites W2416735792 @default.
• W2004348977 cites W2468224652 @default.
• W2004348977 doi "https://doi.org/10.1016/j.yexcr.2005.09.014" @default.
• W2004348977 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16303126" @default.
• W2004348977 hasPublicationYear "2006" @default.
• W2004348977 type Work @default.
• W2004348977 sameAs 2004348977 @default.
• W2004348977 citedByCount "15" @default.
• W2004348977 countsByYear W20043489772012 @default.
• W2004348977 countsByYear W20043489772020 @default.
• W2004348977 countsByYear W20043489772021 @default.
• W2004348977 crossrefType "journal-article" @default.
• W2004348977 hasAuthorship W2004348977A5006497097 @default.
• W2004348977 hasAuthorship W2004348977A5012270222 @default.
• W2004348977 hasConcept C104317684 @default.
• W2004348977 hasConcept C127716648 @default.
• W2004348977 hasConcept C136238340 @default.
• W2004348977 hasConcept C142724271 @default.
• W2004348977 hasConcept C143065580 @default.
• W2004348977 hasConcept C153911025 @default.
• W2004348977 hasConcept C202751555 @default.
• W2004348977 hasConcept C2775962898 @default.
• W2004348977 hasConcept C501734568 @default.
• W2004348977 hasConcept C54009773 @default.
• W2004348977 hasConcept C55493867 @default.
• W2004348977 hasConcept C71924100 @default.
• W2004348977 hasConcept C7263354 @default.
• W2004348977 hasConcept C86803240 @default.
• W2004348977 hasConcept C95444343 @default.
• W2004348977 hasConceptScore W2004348977C104317684 @default.
• W2004348977 hasConceptScore W2004348977C127716648 @default.

• next