FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004349651> ?p ?o ?g. }

• W2004349651 endingPage "378" @default.
• W2004349651 startingPage "371" @default.
• W2004349651 abstract "To investigate whether plasma interleukin-6 (IL-6) is cross-sectionally related to poorer cognitive function and whether a baseline plasma IL-6 measurement can predict risk for decline in cognitive function in longitudinal follow-up of a population-based sample of nondisabled elderly people.A prospective cohort study of 779 high-functioning men and women aged 70 to 79 from the MacArthur Study of Successful Aging was conducted. Regression modeling was used to investigate whether baseline IL-6 levels (classified by tertiles) were associated with initial cognitive function and whether IL-6 levels predicted subsequent declines in cognitive function from 1988 to 1991 (2.5-year follow-up) and from 1988 to 1995 (7-year follow-up).Subjects in the highest tertile for plasma IL-6 were marginally more likely to exhibit poorer baseline cognitive function (i.e., scores below the median), independent of demographic status, social status, health and health behaviors, and other physiologic variables (odds ratio [OR] = 1.46; 95% CI: 0.97, 2.20). At 2.5 years, those in both the second tertile of IL-6 (OR = 2.21; 95% CI: 1.44, 3.42) and the third tertile (OR = 2.03; 95% CI: 1.30, 3.19) were at increased risk of cognitive decline even after adjusting for all confounders. At 7 years of follow-up, only those in the highest IL-6 tertile were significantly more likely to exhibit declines in cognition (OR = 1.90; 95% CI: 1.14, 3.18) after adjustment for all confounders.The results suggest a relationship between elevated baseline plasma IL-6 and risk for subsequent decline in cognitive function. These findings are consistent with the hypothesized relationship between brain inflammation, as measured here by elevated plasma IL-6, and neuropathologic disorders." @default.
• W2004349651 created "2016-06-24" @default.
• W2004349651 creator A5011671341 @default.
• W2004349651 creator A5018378907 @default.
• W2004349651 creator A5023514892 @default.
• W2004349651 creator A5035665078 @default.
• W2004349651 creator A5076106644 @default.
• W2004349651 creator A5091406579 @default.
• W2004349651 date "2002-08-13" @default.
• W2004349651 modified "2023-10-18" @default.
• W2004349651 title "Interleukin-6 and risk of cognitive decline: MacArthur Studies of Successful Aging" @default.
• W2004349651 cites W157966126 @default.
• W2004349651 cites W1899137651 @default.
• W2004349651 cites W1953027527 @default.
• W2004349651 cites W1977092597 @default.
• W2004349651 cites W1977892679 @default.
• W2004349651 cites W1979341891 @default.
• W2004349651 cites W1988715003 @default.
• W2004349651 cites W1993537924 @default.
• W2004349651 cites W2001642972 @default.
• W2004349651 cites W2004898597 @default.
• W2004349651 cites W2023207814 @default.
• W2004349651 cites W2024501220 @default.
• W2004349651 cites W2036244819 @default.
• W2004349651 cites W2054893928 @default.
• W2004349651 cites W2062267403 @default.
• W2004349651 cites W2080742766 @default.
• W2004349651 cites W2081219796 @default.
• W2004349651 cites W2093844611 @default.
• W2004349651 cites W2120704640 @default.
• W2004349651 cites W2122942786 @default.
• W2004349651 cites W2142449610 @default.
• W2004349651 doi "https://doi.org/10.1212/wnl.59.3.371" @default.
• W2004349651 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12177370" @default.
• W2004349651 hasPublicationYear "2002" @default.
• W2004349651 type Work @default.
• W2004349651 sameAs 2004349651 @default.
• W2004349651 citedByCount "469" @default.
• W2004349651 countsByYear W20043496512012 @default.
• W2004349651 countsByYear W20043496512013 @default.
• W2004349651 countsByYear W20043496512014 @default.
• W2004349651 countsByYear W20043496512015 @default.
• W2004349651 countsByYear W20043496512016 @default.
• W2004349651 countsByYear W20043496512017 @default.
• W2004349651 countsByYear W20043496512018 @default.
• W2004349651 countsByYear W20043496512019 @default.
• W2004349651 countsByYear W20043496512020 @default.
• W2004349651 countsByYear W20043496512021 @default.
• W2004349651 countsByYear W20043496512022 @default.
• W2004349651 countsByYear W20043496512023 @default.
• W2004349651 crossrefType "journal-article" @default.
• W2004349651 hasAuthorship W2004349651A5011671341 @default.
• W2004349651 hasAuthorship W2004349651A5018378907 @default.
• W2004349651 hasAuthorship W2004349651A5023514892 @default.
• W2004349651 hasAuthorship W2004349651A5035665078 @default.
• W2004349651 hasAuthorship W2004349651A5076106644 @default.
• W2004349651 hasAuthorship W2004349651A5091406579 @default.
• W2004349651 hasConcept C118552586 @default.
• W2004349651 hasConcept C126322002 @default.
• W2004349651 hasConcept C142724271 @default.
• W2004349651 hasConcept C144024400 @default.
• W2004349651 hasConcept C149923435 @default.
• W2004349651 hasConcept C156957248 @default.
• W2004349651 hasConcept C15744967 @default.
• W2004349651 hasConcept C169900460 @default.
• W2004349651 hasConcept C185711340 @default.
• W2004349651 hasConcept C188816634 @default.
• W2004349651 hasConcept C201903717 @default.
• W2004349651 hasConcept C2777895361 @default.
• W2004349651 hasConcept C2779134260 @default.
• W2004349651 hasConcept C2779483572 @default.
• W2004349651 hasConcept C2908647359 @default.
• W2004349651 hasConcept C2984863031 @default.
• W2004349651 hasConcept C71924100 @default.
• W2004349651 hasConcept C72563966 @default.
• W2004349651 hasConcept C74909509 @default.
• W2004349651 hasConcept C77350462 @default.
• W2004349651 hasConcept C99454951 @default.
• W2004349651 hasConceptScore W2004349651C118552586 @default.
• W2004349651 hasConceptScore W2004349651C126322002 @default.
• W2004349651 hasConceptScore W2004349651C142724271 @default.
• W2004349651 hasConceptScore W2004349651C144024400 @default.
• W2004349651 hasConceptScore W2004349651C149923435 @default.
• W2004349651 hasConceptScore W2004349651C156957248 @default.
• W2004349651 hasConceptScore W2004349651C15744967 @default.
• W2004349651 hasConceptScore W2004349651C169900460 @default.
• W2004349651 hasConceptScore W2004349651C185711340 @default.
• W2004349651 hasConceptScore W2004349651C188816634 @default.
• W2004349651 hasConceptScore W2004349651C201903717 @default.
• W2004349651 hasConceptScore W2004349651C2777895361 @default.
• W2004349651 hasConceptScore W2004349651C2779134260 @default.
• W2004349651 hasConceptScore W2004349651C2779483572 @default.
• W2004349651 hasConceptScore W2004349651C2908647359 @default.
• W2004349651 hasConceptScore W2004349651C2984863031 @default.
• W2004349651 hasConceptScore W2004349651C71924100 @default.
• W2004349651 hasConceptScore W2004349651C72563966 @default.
• W2004349651 hasConceptScore W2004349651C74909509 @default.
• W2004349651 hasConceptScore W2004349651C77350462 @default.

• next