FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004351373> ?p ?o ?g. }

• W2004351373 endingPage "S46" @default.
• W2004351373 startingPage "S27" @default.
• W2004351373 abstract "Over a century ago the intact cortex was proposed to contribute to recovery from unilateral brain injury, but its possible role in functional outcome has become more appreciated in recent years as a result of anatomic, metabolic and behavioral studies. Although use of the contralesional limb is naturally impaired after sensorimotor cortex injury, neural and astrocytic events in the intact hemisphere may give rise to, and may be influenced by, an enhanced ability to compensate for lost motor function. The debate is still open as to whether the neural changes are generally compensatory in nature, with activity in the homotopic cortex leading to greater capability in the nonimpaired limb, or whether they are actually a matter of reorganization in the homotopic cortex leading to connections to denervated targets in the opposite hemisphere, thus allowing the homotopic cortex to control motor programs there. Although both phenomena may occur to some degree, there is mounting evidence in support of the former view. Careful behavioral techniques have been developed that can expose compensatory tricks, and the time course of these behaviors correlates well with anatomic data. Moreover, if the intact cortex sustains a second lesion after recovery from the first, forelimb sensorimotor function specific to the first-impaired side of the body is not worsened. Partial denervation of callosal fibers coming from the injured hemisphere, plus preferential use of the good forelimb caused by a cortical injury, may increase trophic factors in the intact hemisphere. These and related events seem to provide a growth-favorable environment there that permits motor learning in the intact forelimb at a level of skill exceeding that which a normal animal can attain in the same period of time. There are anecdotal cases in human neurologic patients that are consistent with these findings. For example, a colleague of the authors who sustained a unilateral infarction that rendered his dominant right hand severely impaired noticed that soon after the stroke he was able to use his left hand for writing and computers as well as he had ever used his right hand. Cross-midline placing tests also indicate that the structural events observed in the intact cortex may potentiate projections to the damaged hemisphere. These changes may help restore the capacity of tactile information projecting to the intact hemisphere to control limb placing in the impaired forelimb. Neural events in the injured hemisphere can be affected by behavior differently than the neural events in the intact hemisphere. Different therapeutic strategies might well be used on opposing limbs at different times after unilateral sensorimotor cortex injury to optimize recovery (and, indeed, to avoid exaggerating the insult). Finally, the details of reorganization in both hemispheres differ greatly depending on the type of brain injury sustained (eg, in stroke versus Parkinson's disease), suggesting that an approach that considers the role of both hemispheres is likely to be beneficial in research on a broad variety of brain pathologies." @default.
• W2004351373 created "2016-06-24" @default.
• W2004351373 creator A5027671009 @default.
• W2004351373 creator A5060876856 @default.
• W2004351373 creator A5087782377 @default.
• W2004351373 date "2003-02-01" @default.
• W2004351373 modified "2023-10-17" @default.
• W2004351373 title "Should the injured and intact hemispheres be treated differently during the early phases of physical restorative therapy in experimental stroke or parkinsonism?" @default.
• W2004351373 cites W1889533143 @default.
• W2004351373 cites W1920845131 @default.
• W2004351373 cites W1967470495 @default.
• W2004351373 cites W1968772061 @default.
• W2004351373 cites W1969188229 @default.
• W2004351373 cites W1974782589 @default.
• W2004351373 cites W1980493150 @default.
• W2004351373 cites W1984626876 @default.
• W2004351373 cites W1987340975 @default.
• W2004351373 cites W1991296384 @default.
• W2004351373 cites W1994407844 @default.
• W2004351373 cites W1994993953 @default.
• W2004351373 cites W1996342572 @default.
• W2004351373 cites W1997774889 @default.
• W2004351373 cites W2001908895 @default.
• W2004351373 cites W2005346746 @default.
• W2004351373 cites W2007000124 @default.
• W2004351373 cites W2008166548 @default.
• W2004351373 cites W2013684420 @default.
• W2004351373 cites W2021551531 @default.
• W2004351373 cites W2023388136 @default.
• W2004351373 cites W2023760861 @default.
• W2004351373 cites W2027110288 @default.
• W2004351373 cites W2027868342 @default.
• W2004351373 cites W2030589082 @default.
• W2004351373 cites W2032547435 @default.
• W2004351373 cites W2038636807 @default.
• W2004351373 cites W2044443383 @default.
• W2004351373 cites W2049802056 @default.
• W2004351373 cites W2051895625 @default.
• W2004351373 cites W2059407399 @default.
• W2004351373 cites W2061861873 @default.
• W2004351373 cites W2063590057 @default.
• W2004351373 cites W2066408673 @default.
• W2004351373 cites W2067281910 @default.
• W2004351373 cites W2075112177 @default.
• W2004351373 cites W2078490096 @default.
• W2004351373 cites W2080642022 @default.
• W2004351373 cites W2081869387 @default.
• W2004351373 cites W2094936110 @default.
• W2004351373 cites W2101725281 @default.
• W2004351373 cites W2115659532 @default.
• W2004351373 cites W2118981271 @default.
• W2004351373 cites W2138640945 @default.
• W2004351373 cites W2140626683 @default.
• W2004351373 cites W2141626414 @default.
• W2004351373 cites W2141711957 @default.
• W2004351373 cites W2153092987 @default.
• W2004351373 cites W2159053023 @default.
• W2004351373 cites W2164591549 @default.
• W2004351373 cites W2168533684 @default.
• W2004351373 cites W2411637269 @default.
• W2004351373 cites W2433773999 @default.
• W2004351373 cites W2464790579 @default.
• W2004351373 cites W2595532722 @default.
• W2004351373 cites W4247023882 @default.
• W2004351373 cites W4247178258 @default.
• W2004351373 cites W4251163728 @default.
• W2004351373 cites W4253162203 @default.
• W2004351373 doi "https://doi.org/10.1016/s1047-9651(02)00055-4" @default.
• W2004351373 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12625636" @default.
• W2004351373 hasPublicationYear "2003" @default.
• W2004351373 type Work @default.
• W2004351373 sameAs 2004351373 @default.
• W2004351373 citedByCount "43" @default.
• W2004351373 countsByYear W20043513732012 @default.
• W2004351373 countsByYear W20043513732014 @default.
• W2004351373 countsByYear W20043513732015 @default.
• W2004351373 countsByYear W20043513732016 @default.
• W2004351373 countsByYear W20043513732017 @default.
• W2004351373 countsByYear W20043513732019 @default.
• W2004351373 countsByYear W20043513732021 @default.
• W2004351373 crossrefType "journal-article" @default.
• W2004351373 hasAuthorship W2004351373A5027671009 @default.
• W2004351373 hasAuthorship W2004351373A5060876856 @default.
• W2004351373 hasAuthorship W2004351373A5087782377 @default.
• W2004351373 hasConcept C105702510 @default.
• W2004351373 hasConcept C127413603 @default.
• W2004351373 hasConcept C142724271 @default.
• W2004351373 hasConcept C15744967 @default.
• W2004351373 hasConcept C169760540 @default.
• W2004351373 hasConcept C24998067 @default.
• W2004351373 hasConcept C2776805190 @default.
• W2004351373 hasConcept C2777348757 @default.
• W2004351373 hasConcept C2778373776 @default.
• W2004351373 hasConcept C2778646069 @default.
• W2004351373 hasConcept C2780645631 @default.
• W2004351373 hasConcept C2781156865 @default.
• W2004351373 hasConcept C71924100 @default.
• W2004351373 hasConcept C78519656 @default.

• next