Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004353043> ?p ?o ?g. }
- W2004353043 endingPage "309" @default.
- W2004353043 startingPage "304" @default.
- W2004353043 abstract "The estrogen receptor alpha (ERα) is key in regulating normal breast development and function and is closely involved in the onset and progress of cancers. ERα transcriptional activity is mediated through two activation functions, AF1 and AF2, whose activity is tightly regulated in a cell-specific manner through yet unknown processes. Here, we demonstrate that cell–cell junctions generate cell permissiveness to AF1 through an up-regulation of the activity of an AF1 sub-region termed box 1. Moreover, the loss of E-cadherin expression is shown to silence the AF1 activity of ERα, allowing the receptor to mainly act through its AF2. This switch from an AF1 to an AF2 cell permissiveness also consequently results in the attenuation of ERα activity. Therefore, a loss of cell–cell junctions, a key process that occurs during the epithelial–mesenchymal transition, should have a broad impact on ERα transcriptional functions." @default.
- W2004353043 created "2016-06-24" @default.
- W2004353043 creator A5025234580 @default.
- W2004353043 creator A5030942384 @default.
- W2004353043 creator A5043261082 @default.
- W2004353043 creator A5049005189 @default.
- W2004353043 creator A5050363814 @default.
- W2004353043 creator A5056115708 @default.
- W2004353043 creator A5062634740 @default.
- W2004353043 creator A5078919199 @default.
- W2004353043 creator A5079206458 @default.
- W2004353043 creator A5091609857 @default.
- W2004353043 date "2008-01-01" @default.
- W2004353043 modified "2023-10-13" @default.
- W2004353043 title "Loss of E-cadherin-mediated cell contacts reduces estrogen receptor alpha (ERα) transcriptional efficiency by affecting the respective contribution exerted by AF1 and AF2 transactivation functions" @default.
- W2004353043 cites W1571431043 @default.
- W2004353043 cites W1965657782 @default.
- W2004353043 cites W1971960644 @default.
- W2004353043 cites W1977221327 @default.
- W2004353043 cites W1980040001 @default.
- W2004353043 cites W1981306061 @default.
- W2004353043 cites W2002842589 @default.
- W2004353043 cites W2009504099 @default.
- W2004353043 cites W2010401605 @default.
- W2004353043 cites W2022371547 @default.
- W2004353043 cites W2024138902 @default.
- W2004353043 cites W2024905084 @default.
- W2004353043 cites W2037785445 @default.
- W2004353043 cites W2038208040 @default.
- W2004353043 cites W2039298921 @default.
- W2004353043 cites W2041837519 @default.
- W2004353043 cites W2047553717 @default.
- W2004353043 cites W2067980525 @default.
- W2004353043 cites W2078999648 @default.
- W2004353043 cites W2082044237 @default.
- W2004353043 cites W2087367170 @default.
- W2004353043 cites W2147788814 @default.
- W2004353043 cites W2163654826 @default.
- W2004353043 cites W2216094174 @default.
- W2004353043 doi "https://doi.org/10.1016/j.bbrc.2007.10.178" @default.
- W2004353043 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17991426" @default.
- W2004353043 hasPublicationYear "2008" @default.
- W2004353043 type Work @default.
- W2004353043 sameAs 2004353043 @default.
- W2004353043 citedByCount "10" @default.
- W2004353043 countsByYear W20043530432013 @default.
- W2004353043 countsByYear W20043530432014 @default.
- W2004353043 countsByYear W20043530432015 @default.
- W2004353043 countsByYear W20043530432016 @default.
- W2004353043 countsByYear W20043530432019 @default.
- W2004353043 countsByYear W20043530432023 @default.
- W2004353043 crossrefType "journal-article" @default.
- W2004353043 hasAuthorship W2004353043A5025234580 @default.
- W2004353043 hasAuthorship W2004353043A5030942384 @default.
- W2004353043 hasAuthorship W2004353043A5043261082 @default.
- W2004353043 hasAuthorship W2004353043A5049005189 @default.
- W2004353043 hasAuthorship W2004353043A5050363814 @default.
- W2004353043 hasAuthorship W2004353043A5056115708 @default.
- W2004353043 hasAuthorship W2004353043A5062634740 @default.
- W2004353043 hasAuthorship W2004353043A5078919199 @default.
- W2004353043 hasAuthorship W2004353043A5079206458 @default.
- W2004353043 hasAuthorship W2004353043A5091609857 @default.
- W2004353043 hasConcept C104317684 @default.
- W2004353043 hasConcept C121608353 @default.
- W2004353043 hasConcept C126322002 @default.
- W2004353043 hasConcept C1292079 @default.
- W2004353043 hasConcept C1491633281 @default.
- W2004353043 hasConcept C150194340 @default.
- W2004353043 hasConcept C172313692 @default.
- W2004353043 hasConcept C185592680 @default.
- W2004353043 hasConcept C502942594 @default.
- W2004353043 hasConcept C530470458 @default.
- W2004353043 hasConcept C55493867 @default.
- W2004353043 hasConcept C71924100 @default.
- W2004353043 hasConcept C84606932 @default.
- W2004353043 hasConcept C86803240 @default.
- W2004353043 hasConcept C95444343 @default.
- W2004353043 hasConcept C96307122 @default.
- W2004353043 hasConceptScore W2004353043C104317684 @default.
- W2004353043 hasConceptScore W2004353043C121608353 @default.
- W2004353043 hasConceptScore W2004353043C126322002 @default.
- W2004353043 hasConceptScore W2004353043C1292079 @default.
- W2004353043 hasConceptScore W2004353043C1491633281 @default.
- W2004353043 hasConceptScore W2004353043C150194340 @default.
- W2004353043 hasConceptScore W2004353043C172313692 @default.
- W2004353043 hasConceptScore W2004353043C185592680 @default.
- W2004353043 hasConceptScore W2004353043C502942594 @default.
- W2004353043 hasConceptScore W2004353043C530470458 @default.
- W2004353043 hasConceptScore W2004353043C55493867 @default.
- W2004353043 hasConceptScore W2004353043C71924100 @default.
- W2004353043 hasConceptScore W2004353043C84606932 @default.
- W2004353043 hasConceptScore W2004353043C86803240 @default.
- W2004353043 hasConceptScore W2004353043C95444343 @default.
- W2004353043 hasConceptScore W2004353043C96307122 @default.
- W2004353043 hasIssue "2" @default.
- W2004353043 hasLocation W20043530431 @default.
- W2004353043 hasLocation W20043530432 @default.
- W2004353043 hasLocation W20043530433 @default.