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- W2004354003 abstract "Prostatic Intraepithelial Neoplasia (PIN) is widely considered to be a precursor lesion for adenocarcinoma of the prostate. No information is available, however, on the sensitivity of PIN to irradiation or the distribution of residual PIN after radiotherapy. We studied a series of forty-six totally embedded, whole mounted, serially sectioned prostates removed by salvage radical retro pubic prostatectomy following irradiation failure in which no hormonal therapylablation had been undertaken. The mean age o f patients was 6S (56–74) years, the mean dose o f radiotherapy was 7266 (6,000–9,000) cGy, (15 external beam, 27 external beam plus iridium or gold seeds, 3 iodine, and 1 unknown) and the mean interval from irradiation therapy to prostatectomy was 60, (16–145) months. Thirty-two (70%) of the patients had high grade PIN within the prostatectomy specimen. The pattern of PIN was recorded as described by Bostwick and co workerss. The frequency of the different patterns per positive case paralleled in rank those in Bostwick's series of non-irradiated prostates, with the most common to least common per patient being: tufting (78.1 %), micropa pillary (S9.3 %), cribrif orm (34.4 %) and flat, (1S.6%). However, the mean number of foci of PIN per prostate was less than in Bostwick's series (7.1 foci vs. 17 foci). There was no statistically significant difference between groups with or without high grade PIN with regard to various clinical factors (last preoperative serum PSA, age, dose of radiotherapy, interval from irradiation therapy to prostatectomy, Kaplan-Meier survival), or pathologic factors (presence of confined tumor, extracapsular extension, positive surgical margins, seminal vesicle invasion, or positive lymph nodes on permanent sections). We conclude that high grade PIN is common in the prostates o f patients who have failed irradiation therapy and that, theoretically, not all recurrent tumors derive from regrowth of the initial, incompletely eradicated tumor. However, because there was no significant difference between the two groups with regard to the clinical and pathologic parameters listed, we consider it likely that most recurrent tumors derive from the initial incompletely eradicated tumor." @default.
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- W2004354003 date "1995-09-01" @default.
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- W2004354003 title "High Grade Prostatic Intraepithelial Neoplasia in Prostates Removed Following Irradiation Failure in the Treatment of Prostatic Adenocarcinoma" @default.
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- W2004354003 doi "https://doi.org/10.1016/s0344-0338(11)80970-2" @default.
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