FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004354005> ?p ?o ?g. }

• W2004354005 endingPage "1124" @default.
• W2004354005 startingPage "1114" @default.
• W2004354005 abstract "Neurodegenerative diseases such as Alzheimer (AD) and Parkinson (PD) are characterized by abnormal aggregation of misfolded β-sheet-rich proteins, including amyloid-β (Aβ)-derived peptides and tau in AD and α-synuclein in PD. Correct folding and assembly of these proteins are controlled by ubiquitously expressed molecular chaperones; however, our understanding of neuron-specific chaperones and their involvement in the pathogenesis of neurodegenerative diseases is limited. We here describe novel chaperone-like functions for the secretory protein 7B2, which is widely expressed in neuronal and endocrine tissues. In in vitro experiments, 7B2 efficiently prevented fibrillation and formation of Aβ(1-42), Aβ(1-40), and α-synuclein aggregates at a molar ratio of 1:10. In cell culture experiments, inclusion of recombinant 7B2, either in the medium of Neuro-2A cells or intracellularly via adenoviral 7B2 overexpression, blocked the neurocytotoxic effect of Aβ(1-42) and significantly increased cell viability. Conversely, knockdown of 7B2 by RNAi increased Aβ(1-42)-induced cytotoxicity. In the brains of APP/PSEN1 mice, a model of AD amyloidosis, immunoreactive 7B2 co-localized with aggregation-prone proteins and their respective aggregates. Furthermore, in the hippocampus and substantia nigra of human AD- and PD-affected brains, 7B2 was highly co-localized with Aβ plaques and α-synuclein deposits, strongly suggesting physiological association. Our data provide insight into novel functions of 7B2 and establish this neural protein as an anti-aggregation chaperone associated with neurodegenerative disease." @default.
• W2004354005 created "2016-06-24" @default.
• W2004354005 creator A5039265620 @default.
• W2004354005 creator A5053750979 @default.
• W2004354005 creator A5057552749 @default.
• W2004354005 creator A5068969030 @default.
• W2004354005 creator A5074312423 @default.
• W2004354005 creator A5075542021 @default.
• W2004354005 creator A5076002285 @default.
• W2004354005 creator A5080933567 @default.
• W2004354005 date "2013-01-01" @default.
• W2004354005 modified "2023-10-13" @default.
• W2004354005 title "The Neuroendocrine Protein 7B2 Suppresses the Aggregation of Neurodegenerative Disease-related Proteins" @default.
• W2004354005 cites W1507128123 @default.
• W2004354005 cites W1512050447 @default.
• W2004354005 cites W1517461798 @default.
• W2004354005 cites W1527671059 @default.
• W2004354005 cites W1537274817 @default.
• W2004354005 cites W1780440403 @default.
• W2004354005 cites W1790977108 @default.
• W2004354005 cites W1966923623 @default.
• W2004354005 cites W1968721593 @default.
• W2004354005 cites W1972711677 @default.
• W2004354005 cites W1972798313 @default.
• W2004354005 cites W1974978147 @default.
• W2004354005 cites W1980785678 @default.
• W2004354005 cites W1986953518 @default.
• W2004354005 cites W1988190047 @default.
• W2004354005 cites W1989052059 @default.
• W2004354005 cites W1997703895 @default.
• W2004354005 cites W2002559713 @default.
• W2004354005 cites W2025399103 @default.
• W2004354005 cites W2025493128 @default.
• W2004354005 cites W2026077555 @default.
• W2004354005 cites W2031742960 @default.
• W2004354005 cites W2032920422 @default.
• W2004354005 cites W2041032262 @default.
• W2004354005 cites W2052035252 @default.
• W2004354005 cites W2059490725 @default.
• W2004354005 cites W2060458492 @default.
• W2004354005 cites W2062410112 @default.
• W2004354005 cites W2069640452 @default.
• W2004354005 cites W2073838382 @default.
• W2004354005 cites W2073893553 @default.
• W2004354005 cites W2074666700 @default.
• W2004354005 cites W2086053237 @default.
• W2004354005 cites W2089900719 @default.
• W2004354005 cites W2094411486 @default.
• W2004354005 cites W2095943676 @default.
• W2004354005 cites W2096936673 @default.
• W2004354005 cites W2100159830 @default.
• W2004354005 cites W2100864852 @default.
• W2004354005 cites W2105226990 @default.
• W2004354005 cites W2112232744 @default.
• W2004354005 cites W2129105465 @default.
• W2004354005 cites W2138780723 @default.
• W2004354005 cites W2139051378 @default.
• W2004354005 cites W2140445641 @default.
• W2004354005 cites W2144040584 @default.
• W2004354005 cites W2144795344 @default.
• W2004354005 cites W2148389343 @default.
• W2004354005 cites W2169477593 @default.
• W2004354005 cites W2397953569 @default.
• W2004354005 cites W4234635809 @default.
• W2004354005 cites W4240896746 @default.
• W2004354005 cites W4245265700 @default.
• W2004354005 doi "https://doi.org/10.1074/jbc.m112.417071" @default.
• W2004354005 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3542996" @default.
• W2004354005 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23172224" @default.
• W2004354005 hasPublicationYear "2013" @default.
• W2004354005 type Work @default.
• W2004354005 sameAs 2004354005 @default.
• W2004354005 citedByCount "46" @default.
• W2004354005 countsByYear W20043540052013 @default.
• W2004354005 countsByYear W20043540052014 @default.
• W2004354005 countsByYear W20043540052015 @default.
• W2004354005 countsByYear W20043540052016 @default.
• W2004354005 countsByYear W20043540052017 @default.
• W2004354005 countsByYear W20043540052018 @default.
• W2004354005 countsByYear W20043540052019 @default.
• W2004354005 countsByYear W20043540052020 @default.
• W2004354005 countsByYear W20043540052021 @default.
• W2004354005 countsByYear W20043540052022 @default.
• W2004354005 countsByYear W20043540052023 @default.
• W2004354005 crossrefType "journal-article" @default.
• W2004354005 hasAuthorship W2004354005A5039265620 @default.
• W2004354005 hasAuthorship W2004354005A5053750979 @default.
• W2004354005 hasAuthorship W2004354005A5057552749 @default.
• W2004354005 hasAuthorship W2004354005A5068969030 @default.
• W2004354005 hasAuthorship W2004354005A5074312423 @default.
• W2004354005 hasAuthorship W2004354005A5075542021 @default.
• W2004354005 hasAuthorship W2004354005A5076002285 @default.
• W2004354005 hasAuthorship W2004354005A5080933567 @default.
• W2004354005 hasBestOaLocation W20043540051 @default.
• W2004354005 hasConcept C104317684 @default.
• W2004354005 hasConcept C136238340 @default.
• W2004354005 hasConcept C137183658 @default.
• W2004354005 hasConcept C142724271 @default.

• next