Matches in SemOpenAlex for { <https://semopenalex.org/work/W2004355510> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2004355510 endingPage "3" @default.
- W2004355510 startingPage "190" @default.
- W2004355510 abstract "Peyronie's disease is characterized by an acquired penile deviation that may lead to severe penile deformity. It is refractory to most conservative therapy, and surgical correction is therefore the treatment of choice once the disease process has come to a halt. Basic science, as well as our first clinical results on the use of interferons (IFNs), have been promising, suggesting a beneficial effect in the early noncalcified disease stage.From July 1994 to October 1995, 30 patients suffering from early Peyronie's disease were treated with three local injections of 3 million units of IFN-alpha 2b each into the plaque(s). The interval between the injections was 1 week. Patients were assessed clinically and ultrasonographically 6 months after the last injection.Peyronie's disease clinically improved in only 1 case, remained stable in 26 patients and worsened in 3. In 7 patients, a total of 10 plaques at different sites were detected. By ultrasonography the treated plaques now showed calcifications in 3 cases, remained unchanged in 26 and could not be detected in 1 case. Of the 10 new plaques, 2 showed calcifications. Side effects (myalgia, fever) were considerable; in 74 of 90 injections, fever > 38 degrees C occurred, and a total of 8 working days were lost.IFN-alpha 2b, given according to our regimen, is not useful for the treatment of Peyronie's disease in the early stage since the disease progress continues at different sites in about 25% of the patients, and the side effects are untolerable. Our results also demonstrate that local therapy is not indicated in Peyronie's disease." @default.
- W2004355510 created "2016-06-24" @default.
- W2004355510 creator A5000710774 @default.
- W2004355510 creator A5030650465 @default.
- W2004355510 creator A5045000815 @default.
- W2004355510 creator A5052980033 @default.
- W2004355510 date "1997-01-01" @default.
- W2004355510 modified "2023-09-23" @default.
- W2004355510 title "Local interferon-alpha 2b is not an effective treatment in early-stage Peyronie's disease." @default.
- W2004355510 cites W2022673893 @default.
- W2004355510 cites W2119180373 @default.
- W2004355510 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9286652" @default.
- W2004355510 hasPublicationYear "1997" @default.
- W2004355510 type Work @default.
- W2004355510 sameAs 2004355510 @default.
- W2004355510 citedByCount "18" @default.
- W2004355510 countsByYear W20043555102016 @default.
- W2004355510 countsByYear W20043555102017 @default.
- W2004355510 countsByYear W20043555102018 @default.
- W2004355510 countsByYear W20043555102021 @default.
- W2004355510 crossrefType "journal-article" @default.
- W2004355510 hasAuthorship W2004355510A5000710774 @default.
- W2004355510 hasAuthorship W2004355510A5030650465 @default.
- W2004355510 hasAuthorship W2004355510A5045000815 @default.
- W2004355510 hasAuthorship W2004355510A5052980033 @default.
- W2004355510 hasConcept C121332964 @default.
- W2004355510 hasConcept C126322002 @default.
- W2004355510 hasConcept C141071460 @default.
- W2004355510 hasConcept C142424586 @default.
- W2004355510 hasConcept C146357865 @default.
- W2004355510 hasConcept C151730666 @default.
- W2004355510 hasConcept C159047783 @default.
- W2004355510 hasConcept C2776178377 @default.
- W2004355510 hasConcept C2778616394 @default.
- W2004355510 hasConcept C2779134260 @default.
- W2004355510 hasConcept C2779145901 @default.
- W2004355510 hasConcept C2779929075 @default.
- W2004355510 hasConcept C2779982284 @default.
- W2004355510 hasConcept C2781413609 @default.
- W2004355510 hasConcept C2909179924 @default.
- W2004355510 hasConcept C71924100 @default.
- W2004355510 hasConcept C86803240 @default.
- W2004355510 hasConcept C87355193 @default.
- W2004355510 hasConceptScore W2004355510C121332964 @default.
- W2004355510 hasConceptScore W2004355510C126322002 @default.
- W2004355510 hasConceptScore W2004355510C141071460 @default.
- W2004355510 hasConceptScore W2004355510C142424586 @default.
- W2004355510 hasConceptScore W2004355510C146357865 @default.
- W2004355510 hasConceptScore W2004355510C151730666 @default.
- W2004355510 hasConceptScore W2004355510C159047783 @default.
- W2004355510 hasConceptScore W2004355510C2776178377 @default.
- W2004355510 hasConceptScore W2004355510C2778616394 @default.
- W2004355510 hasConceptScore W2004355510C2779134260 @default.
- W2004355510 hasConceptScore W2004355510C2779145901 @default.
- W2004355510 hasConceptScore W2004355510C2779929075 @default.
- W2004355510 hasConceptScore W2004355510C2779982284 @default.
- W2004355510 hasConceptScore W2004355510C2781413609 @default.
- W2004355510 hasConceptScore W2004355510C2909179924 @default.
- W2004355510 hasConceptScore W2004355510C71924100 @default.
- W2004355510 hasConceptScore W2004355510C86803240 @default.
- W2004355510 hasConceptScore W2004355510C87355193 @default.
- W2004355510 hasIssue "2" @default.
- W2004355510 hasLocation W20043555101 @default.
- W2004355510 hasOpenAccess W2004355510 @default.
- W2004355510 hasPrimaryLocation W20043555101 @default.
- W2004355510 hasRelatedWork W1535771998 @default.
- W2004355510 hasRelatedWork W1967416111 @default.
- W2004355510 hasRelatedWork W2004355510 @default.
- W2004355510 hasRelatedWork W2077318868 @default.
- W2004355510 hasRelatedWork W2089355884 @default.
- W2004355510 hasRelatedWork W2163007366 @default.
- W2004355510 hasRelatedWork W2405434905 @default.
- W2004355510 hasRelatedWork W2413521266 @default.
- W2004355510 hasRelatedWork W2419363106 @default.
- W2004355510 hasRelatedWork W2474828202 @default.
- W2004355510 hasVolume "32" @default.
- W2004355510 isParatext "false" @default.
- W2004355510 isRetracted "false" @default.
- W2004355510 magId "2004355510" @default.
- W2004355510 workType "article" @default.