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- W2004355652 abstract "The Plasmodium falciparum food vacuole (FV) is a lysosome-like organelle where erythrocyte hemoglobin digestion occurs. It is a favorite target in the development of antimalarials. We have used a tandem mass spectrometry approach to investigate the proteome of an FV-enriched fraction and identified 116 proteins. The electron microscopy analysis and the Western blot data showed that the major component of the fraction was the FV and, as expected, the majority of previously known FV markers were recovered. Of particular interest, several proteins involved in vesicle-mediated trafficking were identified, which are likely to play a key role in FV biogenesis and/or FV protein trafficking. Recovery of parasite surface proteins lends support to the cytostomal pathway of hemoglobin ingestion as a FV trafficking route. We have identified 32 proteins described as hypothetical in the databases. This insight into FV protein content provides new clues towards understanding the biological function of this organelle in P. falciparum." @default.
- W2004355652 created "2016-06-24" @default.
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- W2004355652 date "2008-09-01" @default.
- W2004355652 modified "2023-10-17" @default.
- W2004355652 title "Food vacuole proteome of the malarial parasite Plasmodium falciparum" @default.
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- W2004355652 doi "https://doi.org/10.1002/prca.200700112" @default.
- W2004355652 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21136929" @default.
- W2004355652 hasPublicationYear "2008" @default.
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